摘要
Abstract
AIM:Vessel-softening granule has been developed based on the mechanism of atherosclerosis lying in deficiency of the liver and kidney and obstruction by phlegm and blood stasis.Clinical observations have proved its effect on the treatment of atherosclerosis. METHODS:The ultrasonic detected atherosclerosis plaques of the cervical arteries were used as the main index,compared with gypenoside tablet.The number of the patients was 57 with 71 plaques in the treatment group and 30 with 38 plaques in the control group. RESULTS:The results showed that in the treatment group,13 plaques disappeared,35 subsided,20 remained unchanged,3 aggravated,while in the control group the corresponding number was 1,3,14 and 20,respectively. The curative effect in the treatment group was better than that in the control group(u=8.157,P< 0.01).Vessel-softening granule has better effects in reducing the thickness of the inner tunica media,improving clinical symptoms,decreasing cholesterol,triglyceride,low density lipoprotein cholesterol,peroxyester, whole blood low shear rate viscosity,fibrinogen and packed erythrocyte volume and increasing super oxide dismutase.[before treatment:(1.49± 0.32),after treatment:(1.79± 0.40)nkat/L,t=4.46,P< 0.01] It has no obvious toxic side effects after long-term administration. CONCLUSION:This study has demonstrated that vessel-softening granule has safe and better therapeutic effect on atherosclerosis.关键词
动脉粥样硬化/中药疗法/冲剂/消痰/滋肾/祛瘀/颈动脉/超氧化物歧化酶/分析分类
医药卫生
