中国临床康复2004，Vol.8Issue(9)：1790-1791,2.
挑筋法诱导佐剂型关节炎大鼠滑膜细胞凋亡的实验研究
Experimental study on the effect of fibrous-tissue-broken pricking on apoptosis of rat synovium in Freund's adjuvant arthritis
童娟 1明顺培 2罗健3
作者信息
- 1. 广州医学院第一附属医院针灸科,广东省广州市,510120
- 2. 广州中医药大学针灸推拿学院经络学教研室,广东省广州市,510407
- 3. 广东省肇庆华佗医院针灸科,广东省广州市,523000
- 折叠
摘要
Abstract
AIM:To study the effect of fibrous-tissue-broken pricking on apoptosis of rat synovium in Freund's adjuvant arthritis. METHODS:A total of 40 SD rats were divided into normal group,model group,medication group,and pricking group,with 10 rats in each group. Freund's adjuvant arthritis model was established and the effect of fibrous-tissue-broken pricking on apoptosis in rat synovium was detected using TUNEL method. RESULTS:The inflammatory rats in model group limped with swollen posterior ankle joint and their body mass decreased,the width of plantar circumference and body mass of (25.48± 2.16) mm and (123.4± 12.8) g,respectively.After the treatment by fibrous-tissue-broken pricking, the swelling relieved,with plantar circumference and body mass of (22.15± 1.17) mm and (132.5± 14.2) g,respectively.There was a significant difference compared with the model group(P< 0.001).TUNEL detection revealed that the apoptosis index of the medication group ( 51.58± 9.73)% was higher than that of the pricking group (43.81± 3.84)% with a significant difference(P< 0.05),in spite of remarkable cell apoptosis in both groups. CONCLUSION:Fibrous-tissue-broken pricking can induce apoptosis of rat synovium in Freund's adjuvant arthritis.Therefore,inflammatory diseases may be treated through suppressing and reducing the overproliferation of synovium.关键词
关节炎/中医疗法/挑治/筋/脱噬作用/佐剂,药物分类
医药卫生引用本文复制引用
童娟,明顺培,罗健..挑筋法诱导佐剂型关节炎大鼠滑膜细胞凋亡的实验研究[J].中国临床康复,2004,8(9):1790-1791,2.
