四川师范大学学报（自然科学版）2001，Vol.24Issue(2)：179-181,3.
新皮啡肽Ⅰ类似物构效关系的研究
Studies on the Structure-activity Relation of Deltorphin I Analogues
摘要
Abstract
Endogenous opioid deltorphin I (DEL I) and its analogues(progressive, stepwise repositioning of Asp from 5 to 7) were synthesized by using solid phase method. It was found that the order (from strong to weak) of analgesic effect and immune activity is Asp5(Asp6),Asp4(Asp7) and Asp4, Asp5, Asp6, Asp5, respectively. This result suggested that the position's alteration of hydrophobic amino-acid residues at C-terminal of DEL I analogues strongly influences biological activities and three dimentional structure of the whole molecule.关键词
新皮啡肽I/阿片受体/固相多肽合成/镇痛/红细胞免疫功能/红细胞玫瑰花结形成细胞分类
生物科学引用本文复制引用
嘉庆,刘萍..新皮啡肽Ⅰ类似物构效关系的研究[J].四川师范大学学报（自然科学版）,2001,24(2):179-181,3.
