中国药理学与毒理学杂志2008，Vol.22Issue(1)：1-8,8.
小补心汤总黄酮对强迫游泳和获得性无助模型动物的抗抑郁作用
Antidepressant effect of total flavonoids extracted from Xiaobuxin-Tang in forced swimming tests and learned helplessness in rats and mice
摘要
Abstract
AIM Xiaobuxin-Tang (XBXT) is a traditional Chinese herbal decoction which is composed of Haematitum, Flos Inulae, Folium Phyllostachydis Henonis and Semen Sojae Preparatum. The present study was to investigate if the total flavonoids extracted from XBXT (XBXT-2) had antidepressant effect. METHODS Forced swimming tests in mice and rats, and learned helplessness (LH) model of rats were adopted to affirm the antidepressant effect of XBXT-2 with the test on spontaneous motor activity. Plasma corticosterone level in the LH rats was measured with ELISA. RESULTS Single administraton of XBXT-2 at the doses of 50 and 100 mg·kg-1 (ig) significantly decreased the duration of immobility time in the forced swimming tests in mice and rats. Researches on LH model of rats indicated that XBXT-2 at doses of 50 and 25 mg·kg-1 markedly reduced the number of escape failure in shuttle box. Meanwhile, the plasma corticosterone level of the LH rats was significantly decreased. XBXT-2 50-200 mg·kg-1 had no effects on spontaneous motor activity in mice. CONCLUSION XBXT-2 possesses significant antidepressant-like effect. The mechanism may involve the inhibition of the hyperaction of the hypothalamic-pituitary-adrenal axis.关键词
小补心汤/抗抑郁药/黄酮类/行为,动物Key words
Xiaobuxin-Tang/ antidepressive agents/ flavonoids/ behavior, animal分类
医药卫生引用本文复制引用
张有志,于能江,袁莉,安磊,赵毅民,肖文彬,罗质璞,李云峰..小补心汤总黄酮对强迫游泳和获得性无助模型动物的抗抑郁作用[J].中国药理学与毒理学杂志,2008,22(1):1-8,8.基金项目
The project supported by National Natural Science Foundation of China (30400600) （30400600）
National Natural Science Foundation of China (30472018) （30472018）
National Basic Research Program of China (2007CB512307) （2007CB512307）
National High Technology Research and Development Program of China (2007AA02Z400) 国家自然科学基金面上项目(30400600) （2007AA02Z400）
国家自然科学基金面上项目(30472018) （30472018）
国家重点基础研究发展规划项目(2007CB512307) （2007CB512307）
国家高技术研究发展计划项目(2007AA02Z400) （2007AA02Z400）
