|国家科技期刊平台
| 注册
首页|期刊导航|中华医学杂志（英文版）|Changes of dopamine transporter function in striatum during acute morphine addiction and its abstinence in rhesus monkey

Changes of dopamine transporter function in striatum during acute morphine addiction and its abstinence in rhesus monkey

XIAO Zhuang-wei CAO Chu-yu WANG Zhao-xin LI Jun-xiong LIAO Hai-yong ZHANG Xue-xin

中华医学杂志（英文版）2006，Vol.119Issue(21)：1802-1807,6.
✕
中华医学杂志（英文版）2006，Vol.119Issue(21)：1802-1807,6.

Changes of dopamine transporter function in striatum during acute morphine addiction and its abstinence in rhesus monkey

Changes of dopamine transporter function in striatum during acute morphine addiction and its abstinence in rhesus monkey

XIAO Zhuang-wei 1CAO Chu-yu 2WANG Zhao-xin 1LI Jun-xiong 2LIAO Hai-yong 2ZHANG Xue-xin3

作者信息

  • 1. Department of Radiology, First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China
  • 2. Guangdong Key Lab of Medical Molecular Imaging, Shantou University, Shantou 515041, China
  • 3. Hefei National Laboratory for Physical Sciences at Microscale,School of Life Sciences, University of Science and Technology of China, Hefei 230027, China
  • 折叠

摘要

Abstract

Background Although dopamine transporter (DAT) is essential for addiction, the effect of additive drugs on DAT function is still controversial, especially for opiates. We investigated the functional changes of dopamine transporter in striatum of rhesus monkeys during acute morphine injection and its abstinence.Methods Four rhesus monkeys, 6 to 9 years old, two male and two female, were examined for 12 days. Single photon emission computed tomography (SPECT) was performed with 99Tcm-TRODAT-1 as the radiopharmaceutical dopamine transporter agent during different stages of acute morphine injection and its abstinence. The ratios of SPECT signal between striatum and cerebellum (ST/CB) were calculated.Results The ST/CB ratio declined significantly on the first day of morphine injection and continued declining with more morphine injections. After abstinence, the ratio increased with time, but was still significantly lower on the 5th day of abstinence than the normal level.Conclusions In rhesus monkey, acute morphine injection has both rapid and lasting effects on DAT by downregulating its function. The decline was partially reversible following morphine abstinence. The results suggest that striatum is one effective target of morphine and that the DAT function in striatum is one indicator for morphine addiction.

关键词

morphine/dopamine transporter/striatum

Key words

morphine/dopamine transporter/striatum

分类

医药卫生

引用本文复制引用

XIAO Zhuang-wei,CAO Chu-yu,WANG Zhao-xin,LI Jun-xiong,LIAO Hai-yong,ZHANG Xue-xin..Changes of dopamine transporter function in striatum during acute morphine addiction and its abstinence in rhesus monkey[J].中华医学杂志（英文版）,2006,119(21):1802-1807,6.

基金项目

This research was supported by grants from the National Natural Science Foundation of China (No. 30420120048 and No.30200068), the Fok Ying Tung Education Foundation (No. 91038)and the Famous Doctor Project of the Department of Health of Guangdong Province (No.21). （No. 30420120048 and No.30200068）

中华医学杂志（英文版）

OACSTPCDMEDLINESCI

0366-6999

访问量0
|
下载量0
段落导航相关论文