中华医学杂志（英文版）2006，Vol.119Issue(21)：1808-1814,7.
Effects of aspirin on atherosclerosis and the cyclooxygenase-2 expression in atherosclerotic rabbits
Effects of aspirin on atherosclerosis and the cyclooxygenase-2 expression in atherosclerotic rabbits
GUO Yi 1WANG Qi-zhang 1TANG Bing-shan 1ZUO Yan-fang 1LI Fang-ming 2JIANG Xin 1WANG Ling 1MA Ke-fu1
作者信息
- 1. Department of Neurology, Second Affiliated Hospital of Jinan University, Shenzhen 518020, China
- 2. Department of Neurology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
- 折叠
摘要
Abstract
Background Atherosclerosis is a complex vascular inflammatory disease. Aspirin is a mainstay in the prevention of vascular complications of atherosclerosis. In this study, the effectiveness of aspirin in suppressing atherosclerosis and the inflammation process was evaluated in rabbits fed with a high fat diet.Methods Eighteen male New Zealand rabbits were randomly divided into 3 groups: control group, untreated cholesterol-fed group, aspirin treated cholesterol-fed group, which were fed for 12 weeks. After 12 weeks, the aorta was harvested for pathologic morphology observation. Immunohistochemical analysis of cyclooxygenase-2 (COX-2), macrophage and vascular smooth muscle cell (VSMC) was performed. The statistical analysis was performed by the statistical program SPSS 10.0.Results The aorta plaque/intima size (P/I) by pathologic morphology observation was 0%, (59.6± 13.7)% and (36.3± 16.5)% in the control, untreated cholesterol-fed group and aspirin treated group, respectively. The maximum plaque thickness, the degree of artery stenosis and the proportion of the intimal circumference occupied by atheroma of the 3 groups were significantly different from each other (P＜0.01). The expression of COX-2 and macrophage in plaque of the aspirin treated group were decreased compared with that in untreated cholesterol-fed group. However, no difference was found in the expression of VSMC between the aspirin treated and the untreated cholesterol-fed group.Conclusion The mechanism of atherosclerosis suppression by aspirin in cholesterol-fed rabbits is related to the inhibition of COX-2 expression together with the reduced inflammation followed by, but not related to the hypolipidemic effects.关键词
aspirin/atherosclerosis/cyclooxygenase-2/rabbitsKey words
aspirin/atherosclerosis/cyclooxygenase-2/rabbits分类
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GUO Yi,WANG Qi-zhang,TANG Bing-shan,ZUO Yan-fang,LI Fang-ming,JIANG Xin,WANG Ling,MA Ke-fu..Effects of aspirin on atherosclerosis and the cyclooxygenase-2 expression in atherosclerotic rabbits[J].中华医学杂志（英文版）,2006,119(21):1808-1814,7.
