中华医学杂志（英文版）2002，Vol.115Issue(12)：1809-1813,5.
阿苯达唑乳剂治疗肝囊型包虫病212例临床疗效观察
Clinical efficacy of albendazole emulsion in treatment of 212 cases of liver cystic hydatidosis
摘要
Abstract
Objective To evaluate the clinical efficacy of a new formulation of albendazole emulsion (AbzE) in cases of liver cystic hydatidosis.Methods Two regimens of AbzE (10 mg*kg-1*d-1 and 12.5 mg*kg-1*d-1) were given to 212 patients with liver cystic hydatidosis in courses ranging from 3 months to more than one year. Assessment of drug efficacy was essentially based on imaging signs with ultrasonography as the main tool. Assessments were performed at the end of different courses and in the follow-up study of 1-4 years after the cessation of therapy.Results At the end of therapeutic courses, the overall cure rate of the 212 cases was 74.5%, with a 99.1% effective rate. In the follow-up study, the cure rate was 83.l%, effective rate was 89.3%, ineffective rate was 0.6%, and recurrence rate was 10.2%. The highest cure rate was observed in cases receiving AbzE 12.5 mg*kg-1*d-1 for 9 months. Retreatment of recurrent cases with AbzE obtained satisfactory results.Conclusions AbzE surpassed other currently used antihydatidosis drugs or formulations with its promising efficacy and mild side effects, and could be recommended as a drug of choice in the treatment of cystic hydatidosis.关键词
囊型包虫病/囊型棘球蚴病/细粒棘球绦虫/阿苯达唑乳剂/临床疗效/化学治疗Key words
cystic echinococcosis/cystic hydatidosis/echinococcus granulosus/albendazole emulsion/clinical efficacy/chemotherapy分类
医药卫生引用本文复制引用
柴君杰,孟贺巴特,焦伟,孙德玉,梁斌,石劲草,付承,李雄,毛一丁,王秀玲,多力坤,古丽拜尔,王燕春,高芳华,肖树华..阿苯达唑乳剂治疗肝囊型包虫病212例临床疗效观察[J].中华医学杂志（英文版）,2002,115(12):1809-1813,5.基金项目
This study was supported by the Ninth National Five-year Plan Key Research Project (No. 96-906-04-09). （No. 96-906-04-09）
