山东医药2001，Vol.41Issue(1)：18-20,3.
凋亡相关基因bcl-2和bax在肺癌中的表达及意义
Expression and significance of Bcl-2 gene and Bax gene in lung cancer
摘要
Abstract
To study the relationship between expression of bcl-2 and baxgene and lung cancer.The bcl-2 and bax gene expression in 51 lung cancer tissues and tissues near cancer were deteeted by immunohistochemical SP method.The positive degree of bcl-2 gene expression in lung cancer was higher than that in tissues near cancer.The positive degree of bax gene expression in lung cancer was lower than that in tissues near cancer.Both differences were very significant（P＜0.01）.There was no correlations between the immunoreactivity of bcl-2 and bax gene and histology，gender，smoking history，clinical subtypes，stage and lymphatic metastasis（P＞0.05）.It suggests that bcl-2 and bax gene may play an important role in tumorgenesis and tumor development.The detection and determination of bcl-2 and bax gene in preinvasive lesions may contribute to the early diagnosis of lung cancer.Some drugs can down-regulate bcl-2 expression and speed apoptosis so as to improve the sensitivity to chemical therapy and radiation.关键词
肺肿瘤 bcl-2基因 bax基因 基因表达 免疫组织化学 凋亡分类
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郭雷,王福昌,杨五计..凋亡相关基因bcl-2和bax在肺癌中的表达及意义[J].山东医药,2001,41(1):18-20,3.
