国际医药卫生导报2009，Vol.15Issue(11)：18-21,4.DOI:10.3760/cma.j.issn.1007-1245.2009.11.007
盐酸戊乙奎醚对内毒素休克兔回肠黏膜形态学的影响
Effect of penehyclidine hydrochloride on intestinal mucosal morphology in the Rabbit Model of Endotoxin Shock
周莉莉 1林小鸿 1吴满辉 1黄子通1
作者信息
- 1. 510120,广州,中山大学附属第二医院急诊科
- 折叠
摘要
Abstract
Objective To observe the effect of different doses of Penehyclidine Hydrochloride(PQN) on intestinal mucosal morphology in the rabbit model of endotoxin shock. Methods Thirty-five healthy White New Zealand rabbits were randomly divided into five groups: control group, shock group, low dose PQN group (0.05 mg/kg), middle dose PQN group (0.15 mg/kg) and high dose PQN group (0.45 mg/kg). The endotoxin shock model was set up by the intravenous infusion with Lipopolysaccharide (LPS). Coincident with the injection of LPS, the different doses of PQN were immediately administered in the low, middle, high dose PQN group, respectively. The intestinal mucosal damage index and morphological changes of intestinal mucosa were observed and assayed under optics microscope and electric microscope at 6 hours after the injection of LPS. The differences among groups were statistically analyzed. Results Compared with the shock group, the intestinal mucosal damage of all PQN treat-ment groups were lessened (P<0.01), even more so in the middle dose PQN group (P<0.01).Conclusions Penehyclidine hydrochloride could relieve the intestinal mucosal damage in the rabbit model of endotoxin shock. Compared with the low and high dose, of PQN, the middle dose of PQN has better protective effect in the rabbit model of endotoxin shock.关键词
盐酸戊乙奎醚/内毒素休克/肠黏膜/形态学Key words
Penehyclidine hydrochloride/Endotoxin shock/Intestinal mucosa/Morphology分类
医药卫生引用本文复制引用
周莉莉,林小鸿,吴满辉,黄子通..盐酸戊乙奎醚对内毒素休克兔回肠黏膜形态学的影响[J].国际医药卫生导报,2009,15(11):18-21,4.
