中国临床康复2002，Vol.6Issue(12)：1852-1853,2.
严重烧伤后早期大鼠肾脏细胞粘附分子1和白介素6的表达与肾功能损害的相关性研究
Expression of intercellular adhesion molecule 1 and interleukin 6 in the rat's kidney after severe burn and its relation with renal injury
刘开军 1魏敏 1刘杰 2鲁华玉 2王德文 2张燕2
作者信息
- 1. Chengdu Medical College,Third Military Medical Universtiy,Chengdu 610083,China
- 2. Academy of Military Medicine,Beijing 100850,China
- 折叠
摘要
Abstract
Objective To clarify the mechanism and provide the basis for prevention and treatment of the early injuries of kidney after severe burn in rats.We observed the expression of intercellular adhesion molecule 1 and interleukin 6 and the early pathological changes in different time.Method Early pathological changes in the kidney were observed by LM and EM.The expression of ICAM 1 were observed by immunohistochemistry,in situ hybridization.The expression of IL 6 was also observed.Result From 5 min to 72 h after burn,the early changes in the kidney included edema,hemorrhage, and congestion,injury of capillary epithelium cells.2ICAM 1 and IL 6 were higher in the kidney 30 min after burn,and from 2 h to 24 h,they were strongest positive,but on 72 h,they were negative.Conclusion ICAM-1 and IL 6 may play important roles in mechanisms of kidney injury,and the major target cells may be the endothelium cells. 关键词
endothelium cell/kidney/ICAM-1/burnKey words
endothelium cell/kidney/ICAM-1/burn分类
医药卫生引用本文复制引用
刘开军,魏敏,刘杰,鲁华玉,王德文,张燕..严重烧伤后早期大鼠肾脏细胞粘附分子1和白介素6的表达与肾功能损害的相关性研究[J].中国临床康复,2002,6(12):1852-1853,2.
