摘要
Abstract
Objective To investigate the clinical significance of ventricular premature contraction (VPC) frequen-cy and sympathetic activity in the patients with coronary artery disease combined with obstructive sleep apnea. Methods 125 patients were categorized by apnea-hypopnea index (AHI) into moderate (AHI<15) or severe (AHI>15) group. Sleep stage was divided into five stages (Wake, S1, S2, S34, and REM). Parameters of heart rate turbulence were calculated. Results VPC frequency was affected significantly by sleep stage (Wake, S2 and REM, F=5.8, P<0.01) and by AHI(F = 8.7, P < 0.01). In Severe group, VPC frequency was higher in REM than in Wake (P=0.011).In contrast, patients in moderate group had fewer VPCs and exhibited sleep stage independence (P=0. 19). Oxygen desat-uration duration per apnea episode was correlated positively with AHI (r2=. 71, P<0.01), and was longer in REM than in non-REM (P <0.01). The heart rate turbulence parameter TS was correlated negatively with oxygen desaturation dura-tion in REM (r2=.06, P=0.014). Conclusion Higher VPC frequency coupled with higher sympathetic activity caused by longer apnea episodes in REM sleep may be one of the reasons for increased nocturnal death in apnca patients.关键词
猝死/心律失常/自主神经系统/冠心病Key words
Sudden death Arrhythmia Autonomic nervous system Coronary disease分类
医药卫生
