眼科学报2003，Vol.19Issue(3)：187-190,4.
Study on Retinal Ganglion Cell Apoptosis after Explosive Injury of Eyeballs in Rabbits
Study on Retinal Ganglion Cell Apoptosis after Explosive Injury of Eyeballs in Rabbits
Suihua Chen 1Zhenping Huang 1Lili Wang 1Tao Jiang 1Bo Wu 1Guiqin Sun1
作者信息
- 1. Department of Ophthalmology, General Hospital of PLA Nanjing Command, Clinical School of Medical College of Nanjing University. Nanjing 210002, China
- 折叠
摘要
Abstract
Purpose: To explore the pathological changes of retinal ganglion cell apoptosis and its relation to the value of glutamate concentration in vitreous body after explosive injury of eyeballs in the rabbits.Method: Similar explosive injury models of eyeballs in 10 adult grey rabbits were made.The rabbits were killed on scheduled time. The retinal tissues of studied eyes and control eyes were obtained for the pathological examination with TUNEL method respectively.The value of glutamate in vitreum of injured eyes was measured and was compared with that of contralateral eyes. Statistical comparison analysis on the experiment data was performed.Result: The value of glutamate in vitreum of injured eyes was significantly higher than that of contralateral eyes in all rabbits in the study. A lot of TUNEL positive cells were observed in the injured eyes. It suggested that apoptosis of the retinal ganglion cells took place.Conclusion: We speculate that apoptosis of the retinal ganglion cells is perhaps among the causes resulting in damage of visual function after explosive injury of eyeballs and that the increasing of the value of glutamate in vitreum possibly associated with apoptosis of the retinal ganglion cells.关键词
explosive injury of eyeball/glutamate/apoptosis/retinaKey words
explosive injury of eyeball/glutamate/apoptosis/retina分类
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Suihua Chen,Zhenping Huang,Lili Wang,Tao Jiang,Bo Wu,Guiqin Sun..Study on Retinal Ganglion Cell Apoptosis after Explosive Injury of Eyeballs in Rabbits[J].眼科学报,2003,19(3):187-190,4.
