波谱学杂志1999，Vol.16Issue(3)：187-194,8.
心肌缺血再灌过程中自由基生成动力学的ESR研究
ESR STUDY ON THE KINETICS OF FREE RADICAL GENERATION IN MYOCARDIAL ISCHEMIA-REPERFUSION PROCESSES
摘要
Abstract
The kinetic changes of free radical generation in myocardial ischemia-reperfusion of rat and guinea pig were studied by means of spin trapping-ESR technique. The results indicated that not only the hydroxyl radical .OH, but also the carbon centered radical R., as well as the alkyloxyl radical RO. were formed in reoxygenation processes, and the .OH radicals always were in majority. An interesting fact was first discovered in our experiments that the signal intensity of .OH radicals in reoxygenation processes increased constantly with time to a maximum and then slowly decayed almost to zero, a kinetics curve of change processes in test samples at different time-points was drawn. Up to date, this kinetic phenomena has not been reported yet in literatures. The kinetics equations for increasing and decreasing processes of hydroxyl free radicals were established respectively. The formation and change of free radicals might be described approximately by degenerate branching chain reaction scheme.关键词
缺血再灌/自由基/动力学/电子自旋共振Key words
Ischemia-reperfusion/Free radical/Kinetics/ESR分类
数理科学引用本文复制引用
陈德文,陆道惠,陈尚恭,郝建明,句海松..心肌缺血再灌过程中自由基生成动力学的ESR研究[J].波谱学杂志,1999,16(3):187-194,8.基金项目
国家自然科学基金资助项目Project Supported by the National Science Foundation of China （）
