中国临床康复2005，Vol.9Issue(15)：188-189,插图15-3,2.
不同年龄大鼠大脑中动脉弹性纤维的变化
Changes of elastic fibers in middle cerebral artery of different aging rats
文灿 1朱星红 1肖桃元 2糜建红 1宋林1
作者信息
- 1. 解放军第三军医大学,解剖教研室,重庆市,400038
- 2. 解放军第三军医大学,中心实验室,重庆市,400038
- 折叠
摘要
Abstract
BACKGROUND: Changes of elastic fibers in middle cerebral artery(MCA)is close related withthe aged cerebrovascular disease.OBJECTIVE: To observe the changes of elastic fibers of MCA in different aging rats.DESIGN: A descriptive and controlled study based on experimental animals.SETTING: Department of anatomy and central laboratory in a university.MATERIALS: Totally 36 healthy Wistar rats with either gender, weighing 200 - 280 g, were selected from the Animal Institute of the third medical military university of Chongqing[certification SCXX (army) 2002-007].INTERVENTIONS: Changes of elastic fibers of MCA of different aging rats were observed with light microscope, transmission electron microscope and image analysis system. MAIN OUTCOME MEASURES: ①) Major outcome: changes of elastic lamella in MCA of different aging rats; ②) Secondary outcome: ultramicrostructural changes of internal lamella under the transmission electron microscope. RESULTS: With the increase of age, the folded extent and quantity of internal elastic lamella were decreased, and the content of elastic fibers were also decreased significantly( P ＜ 0.01 ). However, the ratio of collagen fibers to elastic fibers was increased significantly( P ＜ 0.01 ) . In the aging group above 24 months, the internal elastic lamina thinned, delaminated and disrupted, and the lipid deposited in it. Endothelial cells and smooth muscle cells passed through the internal elastic lamina. CONCLUSION: Changes of elastic fibers may be related with the increased susceptibility to the cerebrovascular disease in aged people.关键词
肌,平滑,血管/解剖学和组织学/肌纤维/内皮/细胞学/年龄因素分类
医药卫生引用本文复制引用
文灿,朱星红,肖桃元,糜建红,宋林..不同年龄大鼠大脑中动脉弹性纤维的变化[J].中国临床康复,2005,9(15):188-189,插图15-3,2.
