生命科学研究2001，Vol.5Issue(1)：1-9,9.
以Lewontin连锁不平衡定位疾病基因
Mapping Disease Gene with Lewontin’s
Linkage Disequilibrium Measure
公国栋 1罗伯特·瑞艾克 1邓红文2
作者信息
- 1. 美国克瑞屯大学医学院 骨质疏松研究所,
- 2. Creighton University Osteoporosis Research Center, 601 North 30th Street, Suite 6730, Omaha, NE
68131, USA
- 折叠
摘要
Abstract
The Lewontin’s D has been considered as one of the best measures of linkage disequilibrium, which is equal to (1－θ)t, where θ is the recombination fraction, and t is the number of generations past since the introduction of the mutation. In addition to the advantages reported previously, we showed that D performs well when disease allele frequency is high. We also showed that a modified equation of D=(1－θ)t applies to dominant, co-dominant, over-dominant and recessive inheritance. We further extended the equation to deterministically estimate θ in the presence recurrent mutation, which is more accurate and simpler than the commonly used ones. Because of these good properties, this equation may have wider applications in linkage disequilibrium mapping of disease genes.关键词
连锁不平衡/疾病基因定位/常见病分类
生物科学引用本文复制引用
公国栋,罗伯特·瑞艾克,邓红文..以Lewontin连锁不平衡定位疾病基因[J].生命科学研究,2001,5(1):1-9,9.
