山东生物医学工程2001，Vol.20Issue(1)：1-9,9.
β-TCP降解和rhBMP-2诱导成骨的关系
RELATIONSHIP BETWEEN DEGRADATION OF β- TCP AND OSTEOGENESIS INDUCED BY rhBMP-2
王丹 1胡蕴玉 2郑昌琼 3赵广跃 2谢克难 3吕荣 2王军2
作者信息
- 1. 济宁医学院际属医院骨科,济宁,272129
- 2. 第四军医大学全军骨科研究所,西安,710032
- 3. 四川联合大学高新技术学院无机材料系,成都,610065
- 折叠
摘要
Abstract
To determine if degradation rate of β - TCP may influence the amounts of bone formation induced by rhBMP- 2.Two kinds of β- TCP/rhBMP- 2 composites(β- TCP1/rhBMP- 2and β- TCP2/rhBMP- 2) which own different degradation rate, were fabricated by combining β - TCP1and β - TCP2 with rhBMP - 2, and implanted into the muscle pouches in the thigh of mice.Histological study, histomorphometry, assay of alkaline phosphatase and degradation amounts of two kinds of β - TCP/rhBMP - 2 were performed after implantation.Both of β - TCP1/rh BMP - 2 and β - TCP2/rhBMP - 2 composite implants showed signs of cartilage and bone formation. The amounts of new bone were increasing with time.But the amounts of new bone in β - TCP1/rhBMP - 2 implants were much greater than in β-TCP2/rhBMP-2 implants at 8- week after implantation(P＜ 0.05). The levels of ALP activity in both groups were increasing with time before 4 weeks postimplantation (P ＜ 0.05), but there was no change during 4～8 weeks. Besides, biodegradation rate of β- TCP1/rhBMP - 2 was higher than that of β - TCP2/rhBMP - 2 at 8 - week after implantation(P＜0.05).The degradation rate of β - TCP can influence the amounts of BMP - inducing bone formation.关键词
磷酸钙类/降解/骨生成Key words
Calcium phosphates Degradation Osteogenesis分类
医药卫生引用本文复制引用
王丹,胡蕴玉,郑昌琼,赵广跃,谢克难,吕荣,王军..β-TCP降解和rhBMP-2诱导成骨的关系[J].山东生物医学工程,2001,20(1):1-9,9.
