中国临床康复2003，Vol.7Issue(13)：1902-1903,2.
针刺对面神经再生逆行轴突转运神经营养因子的影响
Effect of acupuncture on facial nerve regeneration retrograde transport axis-cylinder neurotrophic factor
摘要
Abstract
Aim To explore the mechanism of acupuncture promoting regeneration of peripheral nerve by observing the effect of acupuncture on facial nerve regeneration neurotrophic factor.Methods 180 Newzeland rabbits with the same age and weighed 1.8- 2.8 kg were selected and underwent venous anesthesia by 30 mg/L sodium pentobarbital.Upper bucal branch of facial nerve was separated,exposed and cut under operating magnifying glass.The ends were inlaid into silica gel tube to form regeneration room.After operation,rats were divided by randomly according to body mass and sex into acupuncture group and control group with 90 rats in each group.In each group,90 rabbits were also divided into 3 subgroups randomly with 30 rabbits in each and underwent 125I-BDNF,125I-NT-3 or 125I-NT-4 regeneration intraventrical injection,10 μ l/rabbit.The rabbits in acupuncture group received treatments at 2 and 26 h respectively while rabbits in control received no treatment.At 4,8,24,48 h,brain stems containing nucleus of facial nerve were taken and examined.Results γ counts of 125I-BDNF,125I-NT-3 or 125I-NT-4 in control group got to climax at 12,24 and were [( 1413± 1) ,( 1348± 4) ], [1352± 3) ,( 1286± 3)] [(806± 2),(1137± 2)] respectively,but decreased at 48h and were (594± 1),(624± 2),(354± 2).Fluctuation was obvious.While in acupuncture group,γ counts of 125I-BDNF,125I-NT-3 or 125I-NT-4 were kept a higher level at each time point.Conclusion Acupuncture can promote facial nerve retrograde axis-cylinder transport nurotrophic factor.关键词
针灸疗法/周围神经再生/神经营养因子Key words
acupuncture therapy/peripheral nerve regeneration neurotrophic factor分类
医药卫生引用本文复制引用
吴滨,高炳庆,何竞,李春华,刘屹..针刺对面神经再生逆行轴突转运神经营养因子的影响[J].中国临床康复,2003,7(13):1902-1903,2.基金项目
四川省中医药管理局基金资助(9816) （9816）
