中国临床康复2003，Vol.7Issue(13)：1914-1915,2.
大鼠帕金森综合征模型脑内黑质、尾状核及中缝核的超微结构变化
Ultrastructural changes of substantia nigra,caudate nucleus and raphe nucleus in rat model of parkinsonism
摘要
Abstract
Aim To observe the ultrastructure of substantia nigra,caudate nucleus and raphe nucleus in rat of parkinsonism model and provide experimental basis for etiology and screening of effective drugs.Methods 12 healthy adult Wistar rats were selected without limitation of sex and divided by random drawing lots into experiment group(pethidine hydrochloride was injected,n=9) and control group(normal saline was injected,n=3).Electron microscope was used to observe substantia nigra,caudate nucleus and raphe nucleus stained by methylene blue.Results The pathological changes in the nuclei mentioned above included the crimple and ruture of nucleus membrane,mitochondria degeneration and other degenerative structure such as plenty of primary lysosomes,agglomeration of lipochrome,Golgi complex degeneration and so on.Conclusion The pathological changes of substantia nigra,caudate nucleus and raphe nucleus lead to dysfunction of striatum-substantia nigra-striatum circle.It is the structural basis for the Parkinson's syndrome.关键词
帕金森氏障碍/尾状核/黑质/中缝核/大鼠Key words
Parkinsonian disorders/caudate nucleus/substantia nigra/raphe nuclei/rats分类
医药卫生引用本文复制引用
魏宝强,暴爱丽,张广新,李开明,牛丽凤,苏丹,崔增红,何晓明,王玉勤,邓芷华,张昆..大鼠帕金森综合征模型脑内黑质、尾状核及中缝核的超微结构变化[J].中国临床康复,2003,7(13):1914-1915,2.基金项目
辽宁省科学基金资助 (9810500304) （9810500304）
