劳动医学2001，Vol.18Issue(1)：19-21,3.
Ⅱ型糖尿病小鼠对镉金属硫蛋白致肾脏毒性的易感性
The Susceptibility of Type-2 Diabetic Mice to Cadmium-metallothionein-induced Nephrotoxicity
逄兵 1金泰 1吴训伟 1黄波 1周袁芬 1蒋学之1
作者信息
摘要
Abstract
［Objective］ The aim of this study was to investigate the susceptibility of type-2 diabetic mice (Umea ob/ob mice) to cadmium-metallothionein (CdMT)-induced nephrotoxicity. ［Methods］ 18 of female ob/ob mice and 18 of their lean litter mates (normal mice) were randomly divided into three groups for each type,and administered subcutaneously with CdMT 5 times in short interval. The different doses of CdMT were given to both types of mice based on the ratio of kidney weight to body weight in order to reach the same level of cadmium in renal cortex. ［Results］ The significant increase in NAG and calcium in urine and in renal cortex was found at the lower level of cadmium in renal cortex in ob/ob mice than in normal mice. ［Conclusion］ The authors concluded that ob/ob mice were more susceptible to CdMT-induced renal damage.关键词
镉金属硫蛋白/肾脏毒性/易感性/Ⅱ型糖尿病小鼠分类
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逄兵,金泰,吴训伟,黄波,周袁芬,蒋学之..Ⅱ型糖尿病小鼠对镉金属硫蛋白致肾脏毒性的易感性[J].劳动医学,2001,18(1):19-21,3.
