国际眼科杂志2007，Vol.7Issue(1)：19-22,4.
Ets-1在链脲左菌素诱导的糖尿病大鼠模型视网膜内表达增强
Increased expression of Ets-1 in the diabetic retina of streptozotocin-induced rat model
杜兆江 1李鹏 2惠延年 1王百忍 3段小莉 3张瑞4
作者信息
- 1. 710032,中国陕西省西安市,第四军医大学西京医院眼科
- 2. 710054,中国陕西省西安市,解放军第451医院眼科
- 3. 710032,中国陕西省西安市,第四军医大学全军神经生物研究所
- 4. 710038,中国陕西省西安市,第四军医大学唐都医院药剂科
- 折叠
摘要
Abstract
AIM: To determine the involvement of Ets-1 in the pathological progress of the experimental diabetic retina.
METHODS: Diabetes was induced by intraperitoneal injection of STZ. Total RNA and Total proteins were isolated from retinas of experimental and control eyes at 4 weeks after STZ-injection and were assessed by Northern blot analysis and Western blot analysis, respectively.RESULTS: Expression of both Ets-1 mRNA and Ets-1 protein was significantly increased in the experimental diabetic rat's retina after STZ-injection compared with the control group (P＜0.001).CONCLUSION: Our results indicated that Ets-1 was involved in the pathological progress of experimental diabetic retina.Further studies should be conducted to focus on the relationship between Ets-1 and VEGF in the diabetic retina.关键词
Ets-1/VEGF/糖尿病视网膜/新生血管Key words
Ets-1/VEGF/diabetic retina/angiogenesis分类
医药卫生引用本文复制引用
杜兆江,李鹏,惠延年,王百忍,段小莉,张瑞..Ets-1在链脲左菌素诱导的糖尿病大鼠模型视网膜内表达增强[J].国际眼科杂志,2007,7(1):19-22,4.
