中国临床药学杂志2004，Vol.13Issue(4)：193-196,4.
单用贝那普利未能满意控制患者血压的联合用药选择:左旋氨氯地平与硝苯地平缓释片的对比分析
Selection of combined drug in the patients with hypertension inadequately controlled by benazepril alone:comparison of the combination of benazepril and levamlodipine with benazepril and nifedepine sustained-release tablet
贾鸣 1潘琪宏 1朱梓丰 1黄麟书 1王迎1
作者信息
- 1. 嘉兴医学院附属第二医院心内科,嘉兴,314000
- 折叠
摘要
Abstract
AIM: To compare the BP-reducing effects and adverse drug reactions of the therapy of combined benazepril and levamlodipine (B/LA) with benazepril and nifedepine sustained-tablet (B/NSr) in the patients with mild or moderate hypertension inadequately controlled by benazepril alone. METHODS: The study was performed on 112 patients with mild or moderate primary hypertension inadequately controlled by Benazeprial alone. The patients were randomly divided into 2 groups. Continued previous benazepril treatment , the B/LA group( n = 56) added levarnlodipine,2.5 mg once daily for 2 wk, the B/NSr group( n = 56)added nifedepine sustained-release tablets, 10 mg once daily for 2wk. Examinations were performed before the patients admitted to the trial. The patients who did not achieve a satisfactory BP-reducing added levamlodipine 2.5 mg twice daily in the B/LA group or nifedepine sustained-release tablet 10 mg twice daily in the B/NSr group. The total combination-treatment period was 4 - 6 wk. RESULTS: Total BP-reducing utility rate of the B/LA group was 85.71%, and that of the B/NSr group was 78.57 % ( P ＞ 0.05), but the obvious BPreducing utility rate in the B/LA Group were 73.21%, which was significantly higher than that in the B/NSr group (57.14 %, P ＜0.05 ), especially the SBP-reducing level in the B/LA group was significantly higher than that of in the B/NSr group (P ＜ 0.01 ). There were 8.93 % adverse drug reactions in the B/LA group and 21.43% in the B/NSr group ( P ＜ 0.01). CONCLUSION: Either of the B/LA or the B/NSr is effective in the treatment of hypertension inadequately controlled by benazepril alone, but the B/LA is more desirable therapy than the B/NSr.关键词
原发性高血性/贝那普利/苯磺酸左旋氨氯地平/硝苯地平缓释片Key words
primary hypertension/benazepril/levarmlodipine/nifedepine sustained-release tablet分类
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贾鸣,潘琪宏,朱梓丰,黄麟书,王迎..单用贝那普利未能满意控制患者血压的联合用药选择:左旋氨氯地平与硝苯地平缓释片的对比分析[J].中国临床药学杂志,2004,13(4):193-196,4.
