中华医学杂志（英文版）2008，Vol.121Issue(19)：1932-1938,7.
Dynamic gadoteridol-enhanced MR imaging in the end of growing long bone of piglets
Dynamic gadoteridol-enhanced MR imaging in the end of growing long bone of piglets
LI Xiao-ming 1QIU Li 2LI Feng 1XIONG Wei 1HU Dao-yu 1YU Cheng 1PENG Wen-jia 1HU Jun-wu 1FENG Ding-yi 3HU Xue-mei 4LI Hong-lian2
作者信息
- 1. Department of Radiology,Tongji Hospital,Tongji Medical College, Hubei 430030,China
- 2. Department of Plastic Surgery,Tongji Hospital,Tongji Medical College, Hubei 430030,China
- 3. Department of Histology,Tongji Medical College, Huazhong University of Science and Technologyk Wuhan,Hubei 430030,China
- 4. Department of Statistics,Tongji Medical College, Huazhong University of Science and Technologyk Wuhan,Hubei 430030,China
- 折叠
摘要
Abstract
Background It is of value to identify the non-invasive means that can accurately reflect the blood supply of epiphysis and is more sensitive in detection of early ischemia of epiphysis than the conventional gadoteridol (Gd)-enhanced SE T1WI. The aim of this study was to evaluate the blood supply of various anatomic regions at the end of normal growing long bone using dynamic Gd-enhanced MR imaging and compare the sensitivities between dynamic Gd-enhanced MR imaging and conventional Gd-enhanced SE T1WI in the detection of decreased blood perfusion of early epiphyseal ischemia.Methods Twenty-seven two-week-old piglets were used in this study. For the study of the end of normal growing long bone, unilateral MR imaging of the distal femur and proximal tibia was performed on eleven piglets. The comparison was made among various anatomic regions (physeal and epiphyseal cartilage, metaphyseal spongiosa, the secondary ossification center and metaphysis) using MRI in terms of the enhancement ratio and speed. Their relationships with the histological findings, including RBC/mm<'2> and vessel distribution, were evaluated. To examine ischemic femoral head, 16 piglets were divided into two groups, with the control group having 8 piglets (involving 16 normal hips) and an ischemicgroup having 8 piglets (involving 16 hips with hyperabduction). In the ischemic group, MR imaging was performed on the hips in the hyperabduction immobilized persistently for 30 minutes. After MRI, the piglets were allowed to ambulate freely for 1 day and the same MR scanning was then repeated in a neutral position. The difference in enhancement ratio and speed of the femoral head between the control and ischemic group were evaluated.Results With regard to the end of normal growing long bone, the enhancement ratio of the metaphyseal spongiosa was greatest among all the anatomic regions (P<0.001). The enhancement ratio of physeal cartilage was greater than that of epiphyseal cartilage (P <0. 001), which was the lowest in all tissues (P <0.001). The enhancement speed of the spongiosa was greater than that of physis but the difference was not significant (P >0.05). The enhancement speed of physis was greater than that of epiphyseal cartilage (P <0.05), which was the lowest among all the tissues (P<0.05). The enhancement ratio and speed were found to be related to the histological findings, including RBC/mm<'2> (R >0.75) and distribution of vessels in the tissues. With ischemic femoral head, the enhancement ratios of physis, anterior part and posterior part of capital femoral epiphysis were significantly lower (P <0.05) and enhanced more slowly (P <0.05) than those of normal femoral head on dynamic Gd-enhanced MR imaging. On conventional Gd-enhanced SE T1WI, however,no apparent decrease in enhancement ratio and speed in ischemic hips was found (P <0.05), when they were compared with those in the normal hips.Conclusions Dynamic gadoteridol-enhanced MR imaging can reveal the blood supply in various anatomic regions of the end of normal growing long bone. It is more sensitive than conventional Gd-enhanced SE TlWl in the detection of early epiphyseal ischemia.关键词
gadoteridol/contrast enhancement/growing bone/blood supplyKey words
gadoteridol/contrast enhancement/growing bone/blood supply分类
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LI Xiao-ming,QIU Li,LI Feng,XIONG Wei,HU Dao-yu,YU Cheng,PENG Wen-jia,HU Jun-wu,FENG Ding-yi,HU Xue-mei,LI Hong-lian..Dynamic gadoteridol-enhanced MR imaging in the end of growing long bone of piglets[J].中华医学杂志（英文版）,2008,121(19):1932-1938,7.
