中国现代医学杂志2005，Vol.15Issue(13)：1938-1940,1947,4.
CO2气腹对肝硬化兔肝功能及血清NO影响的实验研究
Experimental study on influence of CO2 pneumoperitoneum on liver function and serum NO in cirrhosis rabbits
鲁发龙 1陶凯雄 1王国斌 1高峰1
作者信息
- 1. 华中科技大学同济医学院附属协和医院,腹腔镜外科,湖北,武汉,430002
- 折叠
摘要
Abstract
[Objective] To study the effect of CO2 pneumoperitoneum on liver function and serum nitric oxide(NO) in cirrhosis rabbits and the mechanism. [Methods] The CO2 pneumoperitoneum of different pressure and duration was established by closed in model of cirrhosis rabbits. The venous blood sample was taken respectively to analyze liver function and NO. [Results] The level of serum alanine aminotransferase(ALT), aspartate aminotransferase (AST) and NO were slightly higher in limited time postoperative compared to the preoperative in normal rabbits, by the 7th day of postoperation, the level of both enzymes returned to normal values. In cirrhosis rabbits, ALT, AST postoperative increased significantly compared to preoperative levels and didn't returned even the 7th day of postoperation, but the level of NO had no significant differences all times. [Conclusions] CO2 pneumoperitoneum has a serious damage to the liver function in cirrhotic liver, but serum NO response insensitively and can't increase correspondingly.关键词
气腹/肝硬化/肝功能/一氧化氮Key words
pneumoperitoneum/cirrhosis/liver function/nitric oxide分类
医药卫生引用本文复制引用
鲁发龙,陶凯雄,王国斌,高峰..CO2气腹对肝硬化兔肝功能及血清NO影响的实验研究[J].中国现代医学杂志,2005,15(13):1938-1940,1947,4.
