中德临床肿瘤学杂志(英文版)2002，Vol.1Issue(4)：194-198,5.
p53和nm23-H1蛋白表达与食管癌浸润转移的关系
The Correlation of p53 and nm23-H1 Expression with Invasiveness and Metastasis in Esophageal Carcinoma
刘立刚 1潘铁成 1李军 1张霓 1宋定伟 1胡敏1
作者信息
- 1. 武汉华中科技大学同济医学院附属同济医院,430030
- 折叠
摘要
Abstract
Objective To study the relationship between expression of p53 and nm23-H1 and differentiation, invasiveness and metastasis in human esophageal carcinoma, and the correlation between expression of p53 and nm23-H1. Methods Expression of p53 and nm23-H1 in 50 patients with squamous cell carcinoma of esophagus was detected by using immunohistochemical S-P methods.Results 35 cases (70%) and 32 cases (64%) of esophageal squamous cell carcinoma were positive for nm23-H1 protein and p53 protein, respectively. The expression of nm23-H1 was related to lymphatic metastasis (P<0.025), but not related to tumor differentiation, invasiveness, tumor location, tumor length, patient's gender and age(P>0.05). The lymphatic metastasis location positive group had a very lower expression of nm23-H1 and the negative rate was 70.8%, but the negative group had a higher expression and the positive rate was 65.4%. The expression of p53 was related to tumor differentiation and invasiveness(P<0.05), but not related to lymphatic metastasis, tumor location, tumor length, patient's gender and age(P>0.05). Among the three groups, the high differentiation group had the lowest expression of p53 and the positive rate was 29.2%, but the low differentiation group had the highest positive rate (71.4%). As for tumor invasiveness, the group of outer membrane of esophagus infiltrated had the highest p53 protein positive rate (56%), but in the group of mucous or submucous layer infiltrated p53 protein was not detectable. The low expression of nm23-H1 and the high expression of p53 were also correlated. The expression of nm23-H1 and p53 were both correlated with TNM stage of esophageal carcinoma (P<0.05). The better esophageal carcinomas differentiated, the lower nm23-H1 expressed and higher p53 expressed. Conclusion Low expression of nm23-H1 and high expression of p53 play an important role in the progression of squamous cell carcinoma of esophagus. Nm23-H1 might be a gene marker in the prophecy of patients' prognosis and benefit tumor treatment clinically.关键词
食管癌/p53蛋白/nm23-H1蛋白Key words
esophageal carcinoma/p53 protein/nm23-H1 protein分类
医药卫生引用本文复制引用
刘立刚,潘铁成,李军,张霓,宋定伟,胡敏..p53和nm23-H1蛋白表达与食管癌浸润转移的关系[J].中德临床肿瘤学杂志(英文版),2002,1(4):194-198,5.
