半导体学报2008，Vol.29Issue(10)：1947-1955,9.
一种具有片上译码/放大功能的微阵列电路及其与生物纳米系统的集成
A CMOS Microarray with On-Chip Decoder/Amplifier and Its Integration with a Bio-Nano-System
摘要
Abstract
A fully integrated CMOS bio-chip is designed in a SMIC 0.18μm CMOS mixed signal process and successfully integrated with a novel bio-nano-system. The proposed circuit integrates an array of 4×4 (16 pixels) of 19μm× 19μm electrodes, a counter electrode, a current mode preamplifier circuit (CMPA), a digital decoding circuit, and control logics on a single chip. It provides a-1.6～1.6V range of assembly voltage, 8bit potential resolution, and a current gain of 39.8dB with supply voltage of 1.8V. The offset and noise are smaller than 5.9nA and 25.3pArms,respectively. Experimental resuits from on-chip selective assembly of 30nm poly (ethylene glycol) (PEG) coated magnetic nano-particles (MNPs) targeted at biosensor applications are included and discussed to verify the feasibility of the proposed circuits.关键词
CMOS生物芯片/集成CMOS微阵列电路/全集成/电路模式放大器/选择性组装/磁性纳米粒子Key words
CMOS bio-ehip/CMOS integrated microarray/fully integration/current mode preamplifier/selective assembly/magnetic nano-particles分类
信息技术与安全科学引用本文复制引用
张雷,顾臻,余志平,贺祥庆,陈涌..一种具有片上译码/放大功能的微阵列电路及其与生物纳米系统的集成[J].半导体学报,2008,29(10):1947-1955,9.基金项目
Project supported by the National Natural Science Foundation of China (Nos. 60236020,90307016), the Intel Foundation, the University Program ofSMIC,and the Private Research Grant Provided by Dr. Dan Yang in CA, USA国家自然科学基金(批准号:60236020,90307016),Intel基金,SMIC大学计划项目及美国加州Dan Yang博士私人基金资助项目 （Nos. 60236020,90307016）
