中华医学杂志（英文版）2007，Vol.120Issue(22)：1951-1957,7.
Postoperative neuropsychological change and its underlying mechanism in patients undergoing coronary artery bypass grafting
Postoperative neuropsychological change and its underlying mechanism in patients undergoing coronary artery bypass grafting
YIN Yi-qing 1LUO Ai-lun 2GUO Xiang-yang 2LI Li-huan 3HUANG Yu-guang2
作者信息
- 1. Department of Anesthesiology, China-Japan Friendship Hosptial,Beijing 100029, China
- 2. Department of Anesthesiology, Peking Union Medical College Hospital, Beijing 100730, China
- 3. Department of Anesthesiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Cardiovascular Institute, Beijing 100037, China
- 折叠
摘要
Abstract
Background The high incidence of neuropsychologic deficits after cardiac surgery, including cognitive dysfunction and mood status, has significantly influenced the prognosis, outcome of treatment and long-term quality of life of patients. With a circadian secretion pattern, melatonin and cortisol are capable of modulating the human physiological processes and neuropsychological status, whereas disorder of their secretion pattern may lead to many diseases. However, it is unclear whether neuroendocrine variations are related to the neuropsychologic status in patients undergoing coronary artery bypass grafting (CABG). Methods Forty male patients scheduled for CABG with hypothermic cardiopulmonary bypass (CPB) (n=20) or off-pump coronary artery bypass (OPCAB) (n=20) were studied. Blood samples were taken intraoperatively at specific time-points and every 3 hours within the first postoperative 24 hours to determine plasma concentrations of melatonin and cortisol. A neuropsychologic test battery including depression and anxiety was administered preoperatively and 7 to 10 days postoperatively. Statistical methods included the nonparametric analysis, multiple linear regression and cosinor analysis. Results The patients in the CPB group exhibited more severe neuropsychologic deficits and more anxious than those in the OPCAB group after surgery. In both groups, patients were more depressed postoperatively than preoperatively and recovered 3 months after surgery. Depression and anxiety were correlated with some factors of cognitive dysfunctions. In the postoperative 24 hours, 2 patients in the CPB group, and 6 patients in the OPCAB group showed a circadian rhythm of melatonin secretion. As for cortisol secretion, there were 3 patients in the CPB group and 7 in the OPCAB group respectively. Parameters of circadian rhythm of melatonin in the CPB group and those of secretion rhythm of cortisol in both groups were correlated with depression and some neuropsychologic tests. Conclusions The incidence of neuropsychological deficits was higher in patients receiving CABG with CPB than in those without CPB. The status of mood may contribute to the perioperative cognitive dysfunctions. The disordered circadian rhythm of melatonin secretion in patients undergoing CABG with CPB and the disordered cortisol secretion may correlate directly or indirectly through mood with neuropsychological deficits.关键词
neuropsychology/ melatonin/ cortisol/ circadian rhythm/ coronary artery bypass grafting/ anesthesiaKey words
neuropsychology/ melatonin/ cortisol/ circadian rhythm/ coronary artery bypass grafting/ anesthesia分类
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YIN Yi-qing,LUO Ai-lun,GUO Xiang-yang,LI Li-huan,HUANG Yu-guang..Postoperative neuropsychological change and its underlying mechanism in patients undergoing coronary artery bypass grafting[J].中华医学杂志（英文版）,2007,120(22):1951-1957,7.
