河南医科大学学报2000，Vol.35Issue(3)：197-199,3.
血清多胺在肺癌诊断中的应用
The application of polyamines in serum to diagnosis of lung cancer
摘要
Abstract
Aim: To study the diagnostic value of polyamines in serum for lung cancer. Methods:The levels of polyamines in serum of rat-bearing lung cancer were determined by RP-HPLC and the data of polyamines in serum were processed by SPSS software. Results:The serum spermine level was significantly higher in rat-bearing tumor((5.70±1.77) μmol/L) than that in control rat serum ((4.83±1.26) μmol/L) . There was no significant difference between the polyamine levels in serum of rat non-tumor of experiment group (( 4.61±1.83) μmol/L) and of control group (P＞0.05). The spermine level in serum was obviously higher in rat-bearing tumor of experiment group than that in rats without tumor of experiment group (P<0.05). The spermidine level was significantly higher in tumor mouse serum ((8.33±2.64) μmol/L) than that in control mouse serum ((5.53±2.30) μmol/L)(P<0.05) and markedly higher in tumor mouse serum than that in non-tumor mouse serum of experiment group (( 5.39±2.30) μmol/L)(P<0.05), there was no significant difference between the polyamines levels in non-tumor mouse serum and control mouse serum (P>0.05).Conclusion:The level of polyamines in mouse serum is a valuable index for the diagnosis of lung cancer.关键词
肿瘤/大鼠/多胺/血清/RP-HPLCKey words
lung neoplasms/rats/polyamines/serum/RP-HPLC分类
医药卫生引用本文复制引用
吴逸明,张振中,史香林,王新朝..血清多胺在肺癌诊断中的应用[J].河南医科大学学报,2000,35(3):197-199,3.基金项目
河南省自然科学基金资助项目 204022300 （）
