中国组织工程研究与临床康复2007，Vol.11Issue(1)：197-200,4.
组织工程材料表面物理化学性质对细胞相容性的影响
Effects of physical and chemical properties of tissue engineered material surface on cell compatibility
摘要
Abstract
OBJECTIVE: To discuss the influence of physical and chemical properties of tissue engineered material surface on the cell compatibility, involving the surface energy, hydrophilicity/hydrophobicity, chemical structure and active factors loaded on the material surface, point out that the physical and chemical properties of material surface have great influence on the cell compatibility of the material, i.e., explain the cell compatibility of tissue engineered materials.DATA SOURCES: An online search of Pubmed database was undertaken to identify relevant articles published in English from December 1997 to December 2006 using the keywords of "bio-compatibility, bio-compatibility materials, tissue engineering, tissue engineering materials, cell-compatibility". Meanwhile, Chinese relevant articles published from December 1997 to December 2006 were searched in Wanfang database with the same keywords in Chinese.STUDY SELECTION: The data were primarily checked. Inclusive criteria: articles about tissue-engineered materials of biocompatibility. The repetitive studies or Meta analysis were excluded.DATA EXTRACTION: Totally 71 relevant literatures were collected, 33 of which were accorded with the inclusive criteria, and the 38 repetitive ones or with old contents were excluded. Of the 33 involved literatures, 22 dealt with biocompatibility, and 11 with the cell-material compatibility.DATA SYNTHESIS: ① Interaction of tissue-engineered materials with organism: The various interactions of tissue-engineered polymer materials with organism are summarized. It is pointed out that the interactions of materials with organism decide the degree of material-tissue compatibility. The effects of material on the tissue compatibility result from the micromolecular and macroscopic levels, and the chemical effect of the macroscopic level is more important than that of the micromolecular one. ② Influence of the physicochemical properties of the material surface on the cell-material com coatibility:The influences on the cell-material compatibility by the chemical nature and structure, composition, energy, hydrophilicity/hydrophobicity, charges and active factorsloaded on the surface are summarized. The obtained information is the important contents for understanding the biocompatibility of the tissue engineered materials and designing biocompatible materials. CONCLUSION: The physical and chemical properties of the material surface greatly affect the cell-material compatibility. The interaction of cells with the polymer matrix is an index to evaluate the cell compatibility. The degree of the short-term interaction of cells with polymer materials can be evaluated by the degree of adhesion on the surface of the polymer materials, while the long-term interaction can be evaluated by detecting the growth of cells cultured in vitro or implanting the polymer material.关键词
生物相容性/生物相容性材料/组织工程/组织工程材料/细胞相容性/综述文献分类
医药卫生引用本文复制引用
陈宝林,王东安,封麟先..组织工程材料表面物理化学性质对细胞相容性的影响[J].中国组织工程研究与临床康复,2007,11(1):197-200,4.基金项目
内蒙古自治区高等学校科学研究项目(NJ6032)Supported by: a grant from the Scientific Research Program of Universities in Nei Monggol Autonomous Region, No. NJ06032 （NJ6032）
