中国临床康复2004，Vol.8Issue(10)：1974-1975,2.
脑卒中类型、病变程度与血清同型半胱氨酸水平的相关性
Relativity of the type and grade of stroke with the serum homocysteine level
李丰升 1骆晓薇 1贾陆红 1衣晶 1张颖 1陈永森 2陈咏梅2
作者信息
- 1. 北京京煤集团总医院,神经内科,北京市,102300
- 2. 北京京煤集团总医院,检验科,北京市,102300
- 折叠
摘要
Abstract
BACKGROUND: More and more studies prove that homocysteine(Hcy) is one of the possible independent risk factors for cerebrovascular diseases (CVD) . It is a focus of today' s research to observe the effect on the morbidity and recurrence rate of CVD by controlling the Hcy level.OBJECTIVE: To observe the serum Hcy level and the relationship between the serum Hcy level and other familiar risk factors of different typed stroke.DESIGN: Case-control study.SETTING and PARTICIPANTS: Seventy-five inpatients, who were diagnosed as acute CVD by brain CT or MRI in the Neurology Department of General Hospital of Beijing Mining Group from January 2003 to June 2003,were selected. Thirty-six contemporaneous outpatients without cardio-and cerebrovascular diseases, 29 males and 7 females, aged 30 - 70 years, were selected as controls.INTERVENTION: Serum levels of Hcy were assayed with high pressure liquid chromatograph, and levels of blood lipid and sugar were measured with fully automatic biochemical instrument.MAIN OUTCOME MEASURES: Levels of serum Hcy, blood lipid and sugar in the two groups.RESULTS: The levels of serum Hcy were(18. 75 ± 1.8) μmol/L for the stroke group and (12. 84 ±2.36) μmol/L for the control group with significant difference( t = 2. 618, P ＜ 0.05) . The CI group[ (20. 59 ± 1.78)μ mol/L]and TIA group[ (15.6 ± 1.50)μmol/L] ( t = 2. 012, P ＜ 0. 05),but not between the CI and cerebral hemorrhage group, between TIA and cerebral hemorrhage groups( P ＞ 0.05) . The CI group and control group ( t = 2. 872, P ＜ 0.01 ), and between the large CI group[ (34.80 ± 2.41 ]μ mol/L] and the general CI group[ (18. 79 ± 1.62) μmol/L] ( t =2. 463,P ＜ 0. 05). No significant differences were found between the patients with and without hypertension, between the patients with and without hyperlipemia, between the patients with and without CVD history, and between the patients with and without DM.CONCLUSION: High level of Hcy is one of the independent risk factors for CVD, and has no relation with hypertension, hyperlipemia and diabetes. However, the Hcy level is closely related with CI for the different CVD, and the increase in the level of Hcy may be associated with the degree of CI.关键词
脑血管意外/半胱胺酸/血液/危险因素分类
医药卫生引用本文复制引用
李丰升,骆晓薇,贾陆红,衣晶,张颖,陈永森,陈咏梅..脑卒中类型、病变程度与血清同型半胱氨酸水平的相关性[J].中国临床康复,2004,8(10):1974-1975,2.
