眼科学报2000，Vol.16Issue(3)：199-202,4.
Detection of Glutamate and γ-aminobutyric Acid in Vitreous of Patients with Proliferative Diabetic Retinopathy
Detection of Glutamate and γ-aminobutyric Acid in Vitreous of Patients with Proliferative Diabetic Retinopathy
Juan Deng 1De-Zheng Wu 1Rulong Gao1
作者信息
- 1. Zhongshan Ophthalnic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China
- 折叠
摘要
Abstract
Purpose: To study the levels of glutamate and γ-aminobutyric acid (GABA) in vitreous of patients with proliferative diabetic retinopathy(PDR) and to investigate their roles in retinal ischemia.Method: Vitreous samples were collected from 25 patients (27 eyes) with PDR and 14patients ( 14 eyes) with idiopathic macular hole. Glutamate and GABA detection were performed by high-performance liquid chromatography (HPLC).Results: Patients with PDR had significantly higher concentrations of glutamate and GABA than the control group. The glutamate level has a significantly positive correlation with GABA level.Conclusion: Detection of glutamate and GABA in vitreous provides biochemical support for the mechanism and treatment of ischemic retinal damage in patients with PDR.关键词
proliferative diabetic retinopathy/vitreous/amino acidKey words
proliferative diabetic retinopathy/vitreous/amino acid引用本文复制引用
Juan Deng,De-Zheng Wu,Rulong Gao..Detection of Glutamate and γ-aminobutyric Acid in Vitreous of Patients with Proliferative Diabetic Retinopathy[J].眼科学报,2000,16(3):199-202,4.
