中国肺癌杂志2001，Vol.4Issue(3)：200-202,3.
肺癌化疗中顺铂用药方法的临床研究
Clinical study on the using methods of cisplatin in lung cancer chemotherapy
任莉 1侯梅 1罗德云 1陈慧 1何建萍1
作者信息
摘要
Abstract
Objective To compare the therapeutic effectiveness and toxicity between 1-day perfusion and 3-day perfusion of high-dose cisplatin combined chemotherapy for lung cancer. Methods Sixty-four cases of pathologically proved lung cancer were randomized into groups A and B. Group A (32 cases) received cisplatin at d1, and group B (32 cases) received cisplatin at d1-3. Total dosages of cisplatin were same for both groups (100*!mg／m2). Results Delayed vomiting in group B (40.63％) was significantly lower than that of group A (53.13％) (P＜0.05); the early nephrotoxicity rate of group B(25.00％) was lower than that of group A (46.88％), but there was no statistically significant difference between two groups (P＞0.05). The therapeutical response was 62.50％ in group A, and 68.75％ in group B. No significant difference of the chemotherapeutical response was observed between the two groups (P＞0.05). Conclusion In the combined chemotherapy of lung cancer, the division administration of high-dose cisplatin can not only guarantee the therapeutic response, but also abate the gastrotoxicity and the nephrotoxicity of cisplatin.关键词
肺肿瘤/化学疗法/顺铂分类
医药卫生引用本文复制引用
任莉,侯梅,罗德云,陈慧,何建萍..肺癌化疗中顺铂用药方法的临床研究[J].中国肺癌杂志,2001,4(3):200-202,3.
