江苏临床医学杂志2002，Vol.6Issue(3)：200-203,4.
三叶委陵菜乙醇提取物镇痛作用的研究
STUDIES OF ANALGESIC PROPERTIES OF ETHANOLIC EXTRACT FROM POTENTILLA FRENIANA BORNM.VAR.SINICA MIGO
边可君 1徐辉碧 2黄开勋 2韩定献2
作者信息
- 1. 扬州大学医学院
- 2. 华中科技大学药物研究所,湖北武汉,430074
- 折叠
摘要
Abstract
Objective:To evaluate the analgesic effect from the ethanolic extract of Potentilla freyniana Bornm. var. Sinica Migo (PBSM).Methods:The analgesic properties of PBSM were investigated by the classical hot plate test and the writhing test.Results:In the hot plate test,the ethanolic extract of PBSM(0.5g/kg,1.25 g/kg,2.5g/kg,o.p.) significantly delayed the response time to hot-plate thermal stimulation 15,30,60 and 90 min after treatment,and 90 min after treatment,the effect of PBSM (2.5g/kg) was higher than that of aminopyrine (100 mg/kg i.m.).In the writhing test, which is more sensitive for non-steroidal analgesics, the ethanolic extract of PBSM (0.5g/kg,1.25g/kg,2.5g/kg o.p.) dose significantly inhibited the writhes induced by 0.7% acetic acid.Conclusion:Potentilla freyniana Bornm.var.Sinica Migo may have analgesic activity and affirm the claim by traditional medicine practitioners of the use in toothache or some painful conditions.关键词
三叶委陵菜/镇痛作用/热板法/扭体法Key words
Potentilla freyniana Bornm.var.Sinica Migo/Analgesic activity/Hot plate/Writhing test分类
医药卫生引用本文复制引用
边可君,徐辉碧,黄开勋,韩定献..三叶委陵菜乙醇提取物镇痛作用的研究[J].江苏临床医学杂志,2002,6(3):200-203,4.
