中国临床康复2005，Vol.9Issue(21)：202-203,2.
周围神经再生桥接物在周围神经缺损修复中的作用
Effect of peripheral nerve regenerated grafts in repair of peripheral nerve gaps
摘要
Abstract
AIM: Nerve transplantation can be accomplished by various grafts. The regenerated grafts of various kinds of peripheral nerve plays an important role in repair of peripheral nerve gaps.METHODS: The relevant literatures on researches on regenerated grafts of peripheral nerve were collected by retrieval system of Medline database and Wanfang database from 1996 to 2002, including grafts of nerve fiber tissue,non-nerve fiber tissue and artificial synthetic material.RESULTS: There are 3 categories mainly involved in the researches on regenerated grafts of peripheral nerve at present. ① Graft of nerve fiber tissue:It includes autologous nerve, allogeneic nerve and heterogenous nerve. Nerve autograft is still the first choice definitely in treatment of peripheral nerve gaps. But it is difficult to find out the grafts of thick and large peripheral nerve and the complications often present, such as neuroma in providing area and motor-sensory disturbance, resulting in new nerve injury. Grafts of allogeneic and heterogenous nerve are more extensive in sources compared with autologous one, without new injury resulted. And they are applicable from various nerve segments. But the immuno-rejection is existed between host and the grafts. ② Graft on non-nerve fiber tissue: The autograft of non-nerve fiber tissue is provided extensively, for which, more researches are focused on veins and muscles. The effect on peripheral nerve bridged by venous graft is inferior to that by nerve autograft, but superior to that by muscles, tendon and silicon latex. But, due to lack of active factor for nerve regeneration, collapse is easily resulted in bridging chronic gaps. ③ Graft of artificial synthetic material: Artificial synthetic material has satisfactory physiology, is absence of antigen and avoids carcinoma. The foreign body rejection is less after implantation, the collapse dose not happen easily in the bridged lumen of nerve fiber, for which, axon regenerated in proximal nerve can pass through successfully, scar intervention is decreased and the natural repair is achieved by generating into the distal through gaps. For above-mentioned advantages, artificial synthetic material becomes the hot topic in researches of recent years.CONCLUSION: The researches of various kinds are still maintained at the stage of animal experiment. Nerve autograft is still predominated in clinical treatment of peripheral nerve gaps at present. It is expected to carry on further researches on new approaches in clinical treatment.关键词
周围神经/神经再生/综述文献分类
医药卫生引用本文复制引用
翁惠兰..周围神经再生桥接物在周围神经缺损修复中的作用[J].中国临床康复,2005,9(21):202-203,2.基金项目
广东省科学技术研究项目(B2001065) （B2001065）
