中国免疫学杂志2001，Vol.17Issue(1)：20-23,4.
云南西部彝族HLA-DQA1基因构成及中华民族19个华人群体DQA1基因频率的比较分析
PCR-RFLP polymorphism of HLA-DQA1 in Yichu of north Yunnan province and compar ed with other Chinese groups
潘德京 1黄洪莲 1刘泽寰 1陈为民 1林蒋海 1陶洪 2陈荣祥 3吴文言 1徐安龙4
作者信息
- 1. 中山大学生命科学学院,
- 2. 云南省卫生防疫站寄防科,
- 3. 云南澜沧县第一人民医院检验科,
- 4. 广州中山大学生命科学学院生化系,
- 折叠
摘要
Abstract
Objective:To investigate HLA-DQA1 alleles distribution in the Yichu of Yangbi county, Yunnan province, compared with other Chinese group.Methods: PCR -RFLP.Results: Of 8 DQA1 alleles studied, DQA1*0301 (allele frequency 31.63%) is the most common allele in this Yichu, and DQA1*0401 (1.02%) is the rarest. Chi -s quare test shows that Yangbi Yichu has no significant difference with six northe rn Han groups, Man, Singaporean and Uygurs of Xinjiang. In contrast, Buyi, Dai a nd Taiwanese is much more complicated with a significant difference from other g roups. A similar observation was found in Guangdong Han and Guangxi Zhuang. Si mi lar to Kazak, Uygurs showed no significant difference with some of northern Han groups. Tibetans have no significant difference with Kazaks and Singaporean. Conclusion: DQA1 complexity of southern ethnic group is probably result of mutilpl e origin or stress of different environment.Yangbi Yi ethnic group has characte ristic of Northern group.关键词
PCR-RFLP HLA-DQA1 彝族 中华民族 多态性分类
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潘德京,黄洪莲,刘泽寰,陈为民,林蒋海,陶洪,陈荣祥,吴文言,徐安龙..云南西部彝族HLA-DQA1基因构成及中华民族19个华人群体DQA1基因频率的比较分析[J].中国免疫学杂志,2001,17(1):20-23,4.
