现代妇产科进展2001，Vol.10Issue(1)：20-23,4.
卵巢上皮性肿瘤组织中肺耐药蛋白的表达及与化疗耐药的关系
Expression of lung resistance protein and i ts relationship with drug resistance in epithelial ovarian tumor.
刘国艳 1吴小华 1宋俊芬 1冯秋红 1李彦群1
作者信息
摘要
Abstract
Objective:To expl ore the clinical significance of lung resistance protein (LRP) in ovarian epithelial tumors.Methods:The expressions of LRP and P-gp were examined by immunochemical methods in 54 ova rian epithelial carcinomas,15 borderline tumors,20 benign tumors and 18 normal o varian tissues.The relationships among the expression of two factors and clini cal pathologic features,resistance to chemotherapy and prognoses were analyzed.Results:1.The positive rates of LRP and P-gp in ovarian epitheli a l carcinoma were 75.9% and 38.9%,repectively.Of the five borderline tumors 4 we r e LRP-positive and 2 were P-gp-positive.6 benign tumors and 7 normal controls sh o wed LRP positive,while none of the ovarian benign tumors and normal control was found P-gp expression.2.The expression of LRP was associated with presence of ascites,no t with age,FIGO stage,histologic type,grade,residual tumor and the size of t umor.The expression of P-gp was not associated with any clinicopathologic features;3.The response rates to chemotherapy in patients with LRP positive and LRP negative were 50.0% and 84.6%,respectively(P＜0.05),while th at o f P-gp were 40.0% and 69.7% respectively(P＜0.05).4.The prognose s of LRP posit ive or P-gp positive patients are poorer than those of negative patients respect ively. Conclusions:LRP expression in ovarian epithelial carcionma is re lated to drug resistance and it is an useful prognostic factor.关键词
卵巢肿瘤/药物疗法/药物耐受性/组 织学技术分类
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刘国艳,吴小华,宋俊芬,冯秋红,李彦群..卵巢上皮性肿瘤组织中肺耐药蛋白的表达及与化疗耐药的关系[J].现代妇产科进展,2001,10(1):20-23,4.
