中国骨伤2001，Vol.14Issue(4)：204-205,2.
基质金属蛋白酶-3和其组织抑制剂-1在椎间盘中的表达及其意义
Statement of Metalloproteinase-3 and Its Tissue Inhibitor of Metalloproteinnase-1 in Intervertebral Disc and Its Significance
杨圣 1史可中 1安荣泽 1廖文波 1谢锡芬1
作者信息
摘要
Abstract
Objective To detect whether the matrix metalloproteinaes-3 and its tissue inhibitor of metalloproteinase-1 expressed among intervertebral disc and comprehend the pathogenesis of intervertebral disc herniation and degeneration.Methods MMP3 and TIMP1 statement in 60 specimens of disc herniation(classified as protrusions,extrusions,sequestrations) and 16 nonherniated discs were detected by immunohistochemistry(ABC assay).Results Statement of MMP3 observed in prolapsed discs was significantly higher than in nonprolapsed disc.The MMP3 positive cell ration in the extrusion and sequestration types were significantly higher than in the protrusion type.No significant difference of MMP3 positive cell ration was found between the extrusion and sequestration type.Positive statement of TIMP1 were not observed in nonherniated discs the protrusion type while were observed and in the exteusion and sequestration types and there were no significant difference between them.Conclusion Imbalanced statement of MMP3 and TIMP1 in intervertebral disc may induce the intervertebral disc degeneration.Difference in degenerative degrees of intervertibral disc may be the biological basis of different disc herniatied types in clinic.关键词
椎间盘移位免疫组织化学软骨分类
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杨圣,史可中,安荣泽,廖文波,谢锡芬..基质金属蛋白酶-3和其组织抑制剂-1在椎间盘中的表达及其意义[J].中国骨伤,2001,14(4):204-205,2.
