北京大学学报（医学版）2002，Vol.34Issue(3)：204-209,6.
中国30个县(市)1993～2000年神经管畸形在出生人群中的患病率及变动趋势分析
Prevalence of neural tube defects at birth in 30 counties and cities of China, 1993-2000
摘要
Abstract
Objective:To describe the prevalence rates of neural tube defects (NTD) and yearly trends (1993－2000) in China. Methods: All the data were obtained from the Birth Defects Surveillance System in thirty counties/cities of China. The calculation of NTD prevalence rates and time trend analyses were based on the data for live (L) and stillbirths (S) only, the denominator used was total births (L+S). Linear regression analysis of the prevalence rate over years has been used to measure time trends. Results: In the period of 1993－2000, there were 1 264 neural tube defects among 1 189 126 total births in 30 counties/cities in China. The overall neural tube defects rate was 10.63 per 10000 births, and rates were higher (18.99 per 10 000 births) in the year 1993, lower (6.05 per 10 000 births) in 1998. The prevalence rates of anencephaly, spina bifida and encephalocele were 4.71,4.39 and 1.53 per 10 000 births respectively. Of all index NTD cases, anencephaly and spina bifida were most frequent, making up 44.3% and 41.3%, and encephalocele represented 14.4%. The stillbirth proportion was 69.3% over all index NTD cases, 95.4% in anencephaly cases, 43.7% in spina bifida, and 62.6% in encephalocele cases. Linear trend analysis indicated a significant decline for NTD rate (F=11.818, β=－0.814,P=0.014). Analysis by specific defect showed significant declines for the rates of anencephaly (P=0.004) and spina bifida (P=0.026), but no significant annual variation of encephalocele (P=0.227). Results of comparing with data reported from other surveillance systems (1994－1999) showed that the highest NTD rate (9.41 per 10000 births) was seen in China, nearly7 times the lowest rate (1.44 per 10000 births) in England and Wales. Conclusion: The overall neural tube defects rate in 30 counties/cities of China presented a significant downward trend between 1993 and 2000, and China still had the higher neural tube defects prevalence. 关键词
神经管缺损/流行病学/患病率Key words
Neural tube defects/epidemiol/Prevalence分类
社会科学引用本文复制引用
叶荣伟,李松,郑俊池,洪世欣,陈新,王太梅,任爱国,王丽娜,李竹..中国30个县(市)1993～2000年神经管畸形在出生人群中的患病率及变动趋势分析[J].北京大学学报（医学版）,2002,34(3):204-209,6.基金项目
中美预防出生缺陷和残疾合作项目资助Supported by China-US Collaberative project on Birth Defects and Disabilities Prevention （）
