中国临床康复2005，Vol.9Issue(1)：206-208,3.
体温对豚鼠耳蜗电图-脑干听觉诱发电位综合波的影响
Effects of the body temperature on the synthetic wave of electrocochleogram and brain stem auditory evoked potentials in guinea pigs
摘要
Abstract
BACKGROUND: A new method for recording the synthetic wave of electrocochleogram-brain stem auditory evoked potentials(ECochG-BAEP SW)has special clinical significance. The study of effects of hypothermia and hyperthermia on the synthetic wave is significant to define its physiological properties and to guide its clinical application.OBJECTIVE: To observe the effects of hypothermia and hyperthermia on ECochG-BAEP SW.DESIGN: A randomized block design.SETTING: Department of Physiology, Medical College of Jinan University.PARTICIPANTS: The study was performed in the Department of Physiology, Medical College of Jinan University. Adult guinea pigs of either gender weighting 300 - 350 g, provided by the Animal Center of the First Military Medical University of Chinese PLA, were randomly divided into hypothermia group( n = 20) and hyperthermia group( n = 20).INTERVENTIONS: The body temperature of the guinea pigs was decreased step by step with their body contacted with a metal tray filled with ice in hypothermia group, and the body temperature of them was increased stepwise with their body contacted with a hot steel box filled with 50 ℃ circulating water in hyperthermia group.MAIN OUTCOME MEASURES: The waveforms, peak latencies (PL), interpeak latencies(IPL) and wave amplitudes of ECochG-BAEP SW had been observed as the body temperature changed gradually.RESULTS: The waveforms of ECochG-BAEP SW had the characteristics of both BAEP and ECochG, and wave 1 was the most obvious, with body temperatures decreased from 36 ℃ to 25 ℃ and increased from 36 ℃ to 42 ℃. The PL and IPL of ECochG-BAEP SW prolonged more and more as the body temperature was decreased stepwise, and shortened more and more as the body temperature was increased gradually. The amplitudes of wave 1, 2 and 3 of ECochG-BAEP SW became significant smaller as the body temperature was decreased to 30 ℃ or 29 ℃, and the amplitudes of wave 1 and 2 were decreased significantly as the body temperature was increased to 40 ℃.CONCLUSION: The effects of hypothermia and hyperthermia on PL, IPL and wave amplitudes of ECochG-BAEP SW were significant, but its waveforms always had the characteristics of both BAEP and ECochG.关键词
诱发电位/听觉/脑干/耳蜗/体温/豚鼠分类
医药卫生引用本文复制引用
何斯纯,马宁,周卓妍,周丽丽..体温对豚鼠耳蜗电图-脑干听觉诱发电位综合波的影响[J].中国临床康复,2005,9(1):206-208,3.基金项目
广东省医学科研基金课题(342640) （342640）
