首页|期刊导航|中华医学杂志（英文版）|Study on the relationship between level of CD58 expression in peripheral blood mononuclear cell and severity of HBV infection
中华医学杂志（英文版）2005，Vol.118Issue(24)：2072-2076,5.
Study on the relationship between level of CD58 expression in peripheral blood mononuclear cell and severity of HBV infection
Study on the relationship between level of CD58 expression in peripheral blood mononuclear cell and severity of HBV infection
摘要
Abstract
Background As one of the intercellular adhesion molecules, CD58 plays important roles in promotion of the adhesion between T cells and target cells, hyperplasia, activation of T cells and natural killer cells, and balance between Th1 and Th2. We studied the relationship between the levels of CD58 expression in peripheral blood mononuclear cells (PBMCs) and severity of HBV infection. Methods The levels of CD58 mRNA in PBMCs were detected using quantitative reverse transcription PCR. The percentage of CD58 positive cells was detected by flow cytometry in patients and healthy controls. Results The levels of CD58 mRNA and the percentage of CD58 positive cells in patients infected with HBV were significantly higher than that in the control. Based on severity of HBV infection, the patients were classified into four groups. The expression of CD58 increased significantly in an order from mild chronic, moderate chronic, severe chronic to severe hepatitis groups. The levels of CD58 mRNA and the percentage of CD58 positive cells in PBMCs from patients with HBV infection were both positively correlated with serum levels of ALT and AST.Conclusion The level of CD58 expression is related with the severity of HBV infection and the degree of liver damage.关键词
antigen/CD58/hepatitis B virus/expressionKey words
antigen/CD58/hepatitis B virus/expression分类
医药卫生引用本文复制引用
XIE Ming,WANG Xiang-ling,JI Yu-qiang,LI Jie,MENG Zhao-jun,SHI Lin ,YUAN Yu-kang..Study on the relationship between level of CD58 expression in peripheral blood mononuclear cell and severity of HBV infection[J].中华医学杂志（英文版）,2005,118(24):2072-2076,5.基金项目
This study was supported by a grant from the National Natural Science Foundation of China (No. 30371321). （No. 30371321）
