中国临床康复2005，Vol.9Issue(13)：208-209,2.
局部亚低温对脑梗死大鼠的脑保护作用
Protective effects of local sub-hypothermia on the brain of rat with cerebral infarction
曹绪政 1苏志强 2徐建民 1兰杰 1梁军1
作者信息
- 1. 解放军第二一一医院神经内科,黑龙江省哈尔滨市,150080
- 2. 哈尔滨医科大学第一附属医院神经内科,黑龙江省哈尔滨市,150001
- 折叠
摘要
Abstract
BACKGROUND: There is still no satisfactory therapy for thetreatment of cerebral infarction at present. Although sub-hypothermia is effective in the treatment of cerebral infarction, its side effect is relatively more. Local sub-hypothermia might have favorable effects in the treatment of cerebral infarction.OBJECTIVE: To observe the protective effects of local sub-hypothermia on the ischemic brain tissues in rats to further explore its mechanism.DESIGN: A randomized controlled basic study based on the experimental animals.SETTING: Institute of neurology of a university hospital.MATERIALS: The study was conducted in the Animal Laboratory of Neurology, the First College for Clinical Medicine, Harbin Medical University between April 2000 and January 2002. Fifty male Wistar rats(cleanness grade) with a bodyweight of(250 ± 25) g were selected.INTERVENTIONS: Ten rats were randomly selected from the 50 rats and divided into normal group and sham-operation group with 5 rats each. The rest 40 rats were randomly divided into normal temperature cerebral ischemia group and local hypothermia cerebral ischemia group with 20 rats each. Rat cerebral middle-sized arterial ischemia model was established for local sub-hypothermia disposal.MAIN OUTCOME MEASURES: Impacts on cerebral infarction volume,nerve function, and neuron-specific enolase(NSE) of rats in each group.RESULTS: The cerebral infarction volume at 48 hours after embolism in rats was ( 128.95 ± 13.42) or (84.90 ± 11.36) mm3 respectively, nerve function evaluation was( 1.60 ± 0. 24) or (0. 95 ± 0. 17), and serous NSE concentration was(13.55±4.07) or(9.19±3.42) μg/L in either sub-hypothermia group or normal temperature group, which were significantly different from each other.CONCLUSION: Local sub-hypothermia therapy has protective effects on ischemic cerebral neurons.关键词
脑梗塞/低温/神经元特异性烯醇化酶分类
医药卫生引用本文复制引用
曹绪政,苏志强,徐建民,兰杰,梁军..局部亚低温对脑梗死大鼠的脑保护作用[J].中国临床康复,2005,9(13):208-209,2.
