Strong additive effect of calcitriol and cyclosporine A on lymphocyte proliferation in vitro and rat liver allotransplantations in vivoOACSTPCD
Strong additive effect of calcitriol and cyclosporine A on lymphocyte proliferation in vitro and rat liver allotransplantations in vivo
Background Vitamin D3 and its metabolites have been found to exert immunosuppressive effects both in vivo and in vitro. We investigated the synergistic effect of calcitriol and cyclosporine A (CsA) on lymphocyte proliferation…查看全部>>
Background Vitamin D3 and its metabolites have been found to exert immunosuppressive effects both in vivo and in vitro. We investigated the synergistic effect of calcitriol and cyclosporine A (CsA) on lymphocyte proliferation in vitro and graft rejection following rat liver allotransplantations in vivo.Methods Alloantigen driven, human peripheral mononuclear cells' proliferation and cytokine production capacity were tested in the presence or absence of vario…查看全部>>
ZHANG Ai-bin;ZHENG Shu-sen
Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Zhejiang University Key Lab of Combined Multi-Organ Transplantation, Ministry of Health, Hangzhou 310003, China
医药卫生
liver transplantationvitamin Dcyclosporinecytokinelymphocytegraft rejection
liver transplantationvitamin Dcyclosporinecytokinelymphocytegraft rejection
《中华医学杂志（英文版）》 2006 (24)
2090-2095,6
The study was supported by a grant from the National Basic Research Program (973 Program) of China (2003CB515501).
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