中国动脉硬化杂志2009，Vol.17Issue(3)：209-212,4.
冠心病患者外周血单个核细胞基质金属蛋白酶9/组织型金属蛋白酶抑制剂1及磷酸化c-Jun蛋白表达改变与冠状动脉病变特征的相关性
Correlations of Matrix Metalloproteinase-9/Metalloproteinase-1, Phospho-c-Jun Expression in Peripheral Blood Mononuclear Cells and the Characteristics of Atherosclerosis Plaque in Patients with Coronary Heart Disease
摘要
Abstract
Aim To investigate the correlation between the protein expressions of matrix metailoproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1) and phospho-c-Jun in peripheral blood mononuclear cells of patients with coronary heart disease and the characteristics of atherosclerosis plaque combined with the coronary angiogra-phy. Methods 55 patients who had coronary heart disease and underwent an immediate or selective coronary angiog-raphy (CAG) were selected and divided into 3 groups: acute coronary syndrome (ACS) group (n=24), stable angina (SA) group (n=16) and conml group (n=15). MMP-9, TIMP-1 and phospho-c-Jun expressions in peripheral blood mononuclear cells were measured by Western-Blot. Coronary angiograms were scored according to Gensini integration and analysis of the relationship between MMP-9, TIMP-1, phospho-c-Jun, MMP-9/TIMP-1 and Gensini integration by linear correlation. Results ①MMP-9, TIMP-1, phospho-c-Jun and MMP-9/TIMP-1 were significantly increased in ACS group than those in SA group and control group (all P<0.001). ②MMP-9, phospho-c-Jun and MMP-9/TIMP-1 were positively correlated with Gensini integration (separately r=0.433, r=0.476, r=0.457, all P<0.01), but there was no correlation between TIMP-1 and Gensini integration. ③MMP-9 was greatly correlated with phospho-c-Jun in patients with coronary heart disease (r=0.839, P<0.001 ). Conclusions ①MMP-9 and MMP-9/TIMP-1 were significantly increased but imbalanced in the patients with ACS, which suggested a prediction of more complex damage and more vulner-able plaque in coronary artery. ②The activation of c-Jun may contribute to MMP-9 expression during the pathogenesis of atherosclerosis.关键词
急性冠状动脉综合征/外周血单个核细胞/基质金属蛋白酶9/组织型金属蛋白酶抑制剂1/磷酸化c-Jun/冠状动脉造影Key words
Acute Coronary Syndrome/Peripheral Blood Mononuclear Cell/Matrix Metalloproteinase-9/Tis-sue Inhibitor of Metalloproteinase-1 /Phospho-c-Jun/Coronary Angiography分类
医药卫生引用本文复制引用
张绍洁,吴黎明..冠心病患者外周血单个核细胞基质金属蛋白酶9/组织型金属蛋白酶抑制剂1及磷酸化c-Jun蛋白表达改变与冠状动脉病变特征的相关性[J].中国动脉硬化杂志,2009,17(3):209-212,4.基金项目
福建省卫生厅创新课题基金项目(2003-cx-18) （2003-cx-18）
