中国现代医学杂志2005，Vol.15Issue(14)：2092-2095,4.
不稳定型心绞痛患者应用小剂量尿激酶前后内皮源性血管活性物质的变化
Changes of vasoactive substances originated endothelium on patients with unstable angina pectoris treated by low dose of urokinase
王聪侠 1牛小麟 1李永勤 1董新 1朱参战 1张明娟 1梁亮1
作者信息
- 1. 西安交通大学第二医院心内科,陕西,西安,710004
- 折叠
摘要
Abstract
[Objective] To analyze the changes of vasoactive substances originated endothelium in patients with unstable angina pectoris treated by low dose of urokinase and explore mechanisms of the drug to treat the unstable angina pectoris. [Methods] 104 patients of unstable angina pectoris were studied. Their ECG stress tests were abnormal and there were ischemic changes in Holter. Before and after urokinase treatments, endothelin-1, plasma tissue plasminogen activator and its inhibitor-lwere determined. [ Results] Compared with pretreatments, after treatments,the activities of tissue plasminogen activator increased, endothelin-1 and the inhibitor-1 decreased. The changes were significant. [Conclusion] Low dose of urokinase can regulate the vasoactive substances originated endothelium obviously in patients with unstable angina pectoris. The major substances include endothelin-1, plasma tissue plasminogen activator and inhibitor-1. From this mechanism, urokinase can treat coronary heart disease effectively.关键词
心绞痛/尿激酶/内皮/血管活性物质Key words
angina pectoris/urokinase/endothelium/vasoactive substances分类
医药卫生引用本文复制引用
王聪侠,牛小麟,李永勤,董新,朱参战,张明娟,梁亮..不稳定型心绞痛患者应用小剂量尿激酶前后内皮源性血管活性物质的变化[J].中国现代医学杂志,2005,15(14):2092-2095,4.
