心理学报2000，Vol.32Issue(2)：210-216,7.
CNTF对应激大鼠行为障碍和海马CA1神经元损害的作用
EFFECTS OF CILIARY NEUROTROPHIC FACTOR ON BEHAVIORAL DISORDERAND HIPPOCAMPAL CA1 NEURONAL DAMAGE INDUCED BY STRESS IN RATS
摘要
Abstract
Objective The experiment was to investigate into the effects of ciliary neurotrophic factor (CNTF) on behavioral disorder and hippocampal CAl neuronal damage induced by stress in rats. Methods The footshock stress－induced changes of behaviors and morphology of hippocampal CAl neurons during acute or chronic stress in rats, and the effects of CNTF administrated into bilateral hippocampus on the changes were observed with open field test, Nissl stain, Bielschowsky-Gros-Lawrentjew stain and electron microscope. Results The open field behaviors increased and morphology of hippocampal CA1 neurons did not change during acute stress in rats. The open field behaviors decreased and hippoampal CAl neuronal damage occurred during chronic stress. CNTF administrated into bilateral hippocampus had no effect on behavior and morphology of hippocampal CA1 neurons in control and acute stressful rats, but it significantly reduced hippocampal CAl neuronal damage and improved behavioral disorder induced by chronic stress. Conclusion CNTF could improve depressive behavior induced by chronic stress via protection of hippocampal CAl neurons.关键词
睫状神经营养因子/应激/行为/海马CAl神经元。Key words
ciliary neurotrophic factor/stress/behavior/hippocampal CAl neuron分类
医药卫生引用本文复制引用
严进,路长林,汤淑萍,何成,王成海,王雪琦,黄爱军,孟玲,鲍璇,张铁峰..CNTF对应激大鼠行为障碍和海马CA1神经元损害的作用[J].心理学报,2000,32(2):210-216,7.基金项目
本文得到国家自然科学基金(No．39670259，39930080)和军队(九五)医药卫生科研基金(No 96M077，98M079)资助。 （No．39670259，39930080）
