国际眼科杂志2004，Vol.4Issue(2)：211-214,4.
端粒酶催化亚单位TERT在实验性外伤性PVR视网膜前膜的动态表达
Dynamic expression of telomerase catalytic sub-unit in epiretinal membranes of experimental traumatic PVR in rats
康凤英 1薛黎平1
作者信息
- 1. 261042,中国山东省潍坊医学院附属医院眼科中心
- 折叠
摘要
Abstract
AIM: To investigate whether telomerase catalytic sub-unit (TERT) takes part in the regulation of cell proliferation in epiretinal membranes in traumatic proliferative vitreoretinopathy (PVR) and its dynamic change.METHODS: By using S-P technique, immunocytochemi cal staining and HE staining of epiretinal membranes of traumatic PVR were conducted. The results were analyzed by using the computerized image analysis system.RESULTS: At 7, 14, 21, and 28 days after operation,the TERT positive rate was (4.5±2.7)%, (14.2±4.6)%,(13.0±4.8)% and (9.2±2.3)% respectively and the average 4 is 0.0690±0.0213, 0.0912±0.0125, 0.0825±0.0278and 0.0744±0.0159 respectively. The values at day 7were significantly different from those at either day 14 or day 21. The positive rate at day 28 was significantly lower than that at either day 14 or day 21.CONCLUSION: The activation of telomerase may beone of the mechanisms that initiate cell proliferation in epiretinal membranes in PVR. The expression of TERT fluctuates with the PVR course.关键词
外伤性增殖性玻璃体视网膜病变/端粒酶/端粒酶催化亚单位/动物模型/免疫组织化学Key words
traumatic proliferative vitreoretinopathy/telomerase/telomerase catalytic sub-unit (TERT)/animal model/immunocytochemistry分类
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康凤英,薛黎平..端粒酶催化亚单位TERT在实验性外伤性PVR视网膜前膜的动态表达[J].国际眼科杂志,2004,4(2):211-214,4.
