老年心脏病学杂志（英文版）2005，Vol.2Issue(4)：211-215,5.
Plasma N-terminal pro-brain natriuretic peptide levels in elderly patients with isolated diastolic dysfunction
Plasma N-terminal pro-brain natriuretic peptide levels in elderly patients with isolated diastolic dysfunction
Yixin SONG 1Qing LIN 1Xiaomin SHI 1Yunyun QI1
作者信息
- 1. Department of Geriatric Medicine, First Hospital of Beijing University, Beijing 100034, China
- 折叠
摘要
Abstract
To investigate plasma N-terminal pro-brain natriuretic peptide (NT-BNP) levels and to assess their clinical significance in elderly patients with isolated diastolic dysfunction. Methods Plasma NT-BNP level were measured by electrochemiluminescence immunoassay in 34 symptomatic patients (Group 1), 34 asymptomatic patients (Group 2) with isolated diastolic dysfunction, and in 16elderly healthy subjects (control group, Group 3), serving controls. Colored Doppler echocardiography was performed to evaluate the patients' cardiac structures and functions. Results The plasma NT-BNP level in Group 1 was significantly higher than those in Group 2 and Group 3 and increased with the severity of heart failure. There was no significant difference of plasma NT-BNP levels between Group 2 and Group 3 (p＞0.05). A NT-BNP value of 102.75 pg/mL showed a sensitivity of 88.2%, a specificity of 87.5%, and an accuracy of 88.1% for diagnosing diastolic dysfunction. Patients with restrictive filling pattern on echocardiography had higher NTBNP levels than those of impaired relaxation pattern (1961.2±304.9 versus 460. 1±92.7pg/mL, p＜0.001). Conclusion The elevation of plasma NT-BNP level in elderly patients with isolated diastolic dysfunction correlates with the severity of their diastolic abnormalities.The level of plasma NT-BNP has an important clinical value in the diagnosis of elderly patients with isolated diastolic dysfunction.关键词
elderly/isolated diastolic dysfunction/N-terminal pro-brain natriuretic peptide/echocardiographyKey words
elderly/isolated diastolic dysfunction/N-terminal pro-brain natriuretic peptide/echocardiography分类
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Yixin SONG,Qing LIN,Xiaomin SHI,Yunyun QI..Plasma N-terminal pro-brain natriuretic peptide levels in elderly patients with isolated diastolic dysfunction[J].老年心脏病学杂志（英文版）,2005,2(4):211-215,5.
