首页|期刊导航|中华医学杂志（英文版）|Relationship between the level of fasting plasma glucose and beta cell functions in Chinese with or without diabetes
中华医学杂志（英文版）2008，Vol.121Issue(21)：2119-2123,5.
Relationship between the level of fasting plasma glucose and beta cell functions in Chinese with or without diabetes
Relationship between the level of fasting plasma glucose and beta cell functions in Chinese with or without diabetes
摘要
Abstract
Background Type 2 diabetes is a chronic disease characterized by a progressive loss of beta cell functions.However,the evaluation of beta cell functions is either expensive or inconvenient for clinical practice.We aimed to elucidate the association between the changes of insulin responsiveness and the fasting plasma glucose (FPG) during the development of diabetes.Methods A total of 1192 Chinese individuals with normal blood glucose or hyperglycemia were enrolled for the analysis.The early insulinogenic index (△I30/△G30),the area under the curve of insulin (AUC-I),and homeostasis model assessment were applied to evaluate the early phase secretion,total insulin secretion,and insulin resistance respectively.Polynomial regression analysis was performed to estimate the fluctuation of beta cell functions.Results The △I30/△G30 decreased much more rapidly than the AUC-I accompanying with the elevation of FPG.At the FPG of 110 mg/dl (a pre-diabetic stage),the △I30/△G30 lost 50% of its maximum while the AUC-I was still at a compensated normal level.The AUC-I exhibited abnormal and decreased gradually at the FPG of from 130 mg/dl to higher (overt diabetes),while the △I30/△G30 almost remained at 25% of its maximum value.When hyperglycemia continuously existed at >180 mg/dl,beth the △I30/△G30 and AUC-I were totally lost.Conclusion The increased fasting plasma glucose reflects progressive decompensation of beta cell functions,and could be used to guide the strategy of clinical treatments.关键词
fasting plasma glucose/beta cell failure/diabetes mellitusKey words
fasting plasma glucose/beta cell failure/diabetes mellitus分类
医药卫生引用本文复制引用
PANG Can,BAO Yu-qian,WANG Chen,LU Jun-xi,JIA Wei-ping,XIANG Kun-san..Relationship between the level of fasting plasma glucose and beta cell functions in Chinese with or without diabetes[J].中华医学杂志（英文版）,2008,121(21):2119-2123,5.基金项目
This work was supported by the grants from the Key Project from Science and Technology Commission of Shanghai (No.01ZD002(1)),the Program for Outstanding Medical Academic Leader of Shanghai (No.LJ06010),and the National Basic Research Program of China (973 Program) (No.2006CB503901). （No.01ZD002(1）
