中国现代医学杂志2005，Vol.15Issue(1)：21-23,27,4.
一氧化氮在实验大鼠骨折愈合中的作用研究
Function of nitric oxide in fracture healing in experimental rats
迟大明 1范广宇 1朱悦1
作者信息
- 1. 中国医科大学第一临床学院,骨科,辽宁,沈阳,110001
- 折叠
摘要
Abstract
[Objective] To evaluate the possible function of NO in fracture healing. [Methods] 120 Wistar rats were divided into 3 groups including L-arginine, L-NAME and the control group. The closed fractured model of each rat was built in the right femur. The callus of the fractured site was amputated and observed by the gross appearance and HE stain in the 3rd day, the first, second and fourth week after fracture. [Results] The gross observation of fracture in different stage indicated relatively small callus after the L-NAME intake. This was the same with the callus modelliing. Compared to these findings, completely opposite results were seen in the L-arginine group.When compared to the control group, the tendency of fracture healing was seen in the L-NAME group, but it had no significant difference (P =0.1). The degree of remodeling of the bone and fracture healing in the group of L-arginine was stronger than that in L-NAME (P ＜0.05). [Conclusion] L-NAME' s intake will inhibit the process after the fracture, which indicates NO may play an important role in the process of fracture healing.关键词
一氧化氮/骨折/骨折愈合Key words
nitric oxide/fracture/fracture healing分类
医药卫生引用本文复制引用
迟大明,范广宇,朱悦..一氧化氮在实验大鼠骨折愈合中的作用研究[J].中国现代医学杂志,2005,15(1):21-23,27,4.
