老年心脏病学杂志（英文版）2008，Vol.5Issue(1)：21-24,4.
Relationship between interleukin-18 levels and characterization of atherosclerotic plaque and percutaneous coronary intervention
Relationship between interleukin-18 levels and characterization of atherosclerotic plaque and percutaneous coronary intervention
Weihua Li 1Kaimin Lin 1Lei Gao 1Rong Wu 1Qiang Xie 1Yongjun Guo 1Shuhui Dai1
作者信息
- 1. Department of Cardiology,Affiliated First Hospital of Xiamen,Fujian Medical University,Xiamen 361003,China
- 折叠
摘要
Abstract
Background lnterleuldn-18(IL- 18) plays a key role in the development,progression and outcome of coronary artery disease and its complications.However,its variability relation to the characterization of atherosclerotic plaque and percutaneous coronary intervention are still unknown.Methods Fifty four patients with coronary artery disease [22 patients with stable angina (SA) and 32 patients with acute coronary syndrome (ACS)] were enrolled in this study.All patients underwent percutaneous coronary intervention (PCI).The stability of the plaques at the criminal vessels was assessed with analogical IVUS.Serum IL-18 levels were measured at the time points of 5 rain before PCI,and Oh,6h,24h and lmonth after PCI in all patients.Results ACS group consisted mainly of lipidic unstable plaques while SA group of fibrous stable plaques.Moreover,compared with those in SA group,eccentricity index (EI) and remodeling index (RI) were significantly higher in ACS group.Positive remodeling was seen in ACS group while negative or no remodeling in SA group.Further,serum IL-18 levels were significantly elevated in patients with ACS than those in SA group before PCI,increased at Oh,6h,24h after PCI (P＜0.05)and were not significant different at 1 month after PCI from those before PCI.Conclusions There is significant difference in the composition and structural characteristics of atherosclerotic plaques between ACS and UA groups.PCI triggersd and enhances the inflammatory response in a short time.Serum levels of IL- 18 are the predictors of progression of unstable plaque in atherosclerosis.Post-operative complications of PCI might be reduced by inhibiting IL- 18.(J Geriatr Cardiol 2008;5:21-24)关键词
IL-18/coronary artery disease/acute coronary syndromes/IVUS/percutaneous coronary interventionKey words
IL-18/coronary artery disease/acute coronary syndromes/IVUS/percutaneous coronary intervention分类
医药卫生引用本文复制引用
Weihua Li,Kaimin Lin,Lei Gao,Rong Wu,Qiang Xie,Yongjun Guo,Shuhui Dai..Relationship between interleukin-18 levels and characterization of atherosclerotic plaque and percutaneous coronary intervention[J].老年心脏病学杂志（英文版）,2008,5(1):21-24,4.
