中国药理学通报2001，Vol.17Issue(1)：21-25,5.
细胞色素氧化酶P450及其遗传多态性
Cytochrome P450 and genetic polymorphism
摘要
Abstract
Cytochrome P450 enzyme are an important enzyme family in drug metabolism. Human cytochrome P450 enzymes have been studied entensively about their polymorphism in recent years. polymorphism of CYP2C19 and CYP2D6 have been detected at both phenotypic and genotypic level, and their molecular mechanism have been studied entensively, however, the molecular mechanism of other enzymes for exzample CYP2C9,CYP1A1,CYP2E1 et al) is being discussed, though these enzymes possiblely exist polymorphism. The article summarizes the substrates of P450, molucular mechanism of polymorphism, and paticular reference to the effects of this variation on drug metabolism and susceptibility to chemically-induced diseases.关键词
细胞色素氧化酶P450/遗传多态性/分子机制/CYP2C19/CYP2D6/CYP2E1/CYP1A1/CYP3A分类
医药卫生引用本文复制引用
付良青,吴德政..细胞色素氧化酶P450及其遗传多态性[J].中国药理学通报,2001,17(1):21-25,5.
